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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
interleukin 18	ENSG00000150782	IL18	chr11:112143251-112164117:-	Tbio	2177.17
tubulin beta class I	ENSG00000196230	TUBB	chr6:30720201-30725426:+	Tclin	63.1798
TNF receptor superfamily member 10b	ENSG00000120889	TNFRSF10B	chr8:23020133-23069179:-	Tbio	803.635
dickkopf WNT signaling pathway inhibitor 3	ENSG00000050165	DKK3	chr11:11963106-12009769:-	Tbio	463.531
cytidine deaminase	ENSG00000158825	CDA	chr1:20588948-20618908:+	Tchem	968.935
prostate stem cell antigen	ENSG00000167653	PSCA	chr8:142670308-142682724:+	Tbio	204.009
folate hydrolase 1	ENSG00000086205	FOLH1	chr11:49146635-49208670:-	Tchem	897.857
UL16 binding protein 2	ENSG00000131015	ULBP2	chr6:149942000-149949235:+	Tbio	40.1429
phosphatidylinositol 3-kinase catalytic subunit type 3	ENSG00000078142	PIK3C3	chr18:41955206-42087830:+	Tchem	128.383
farnesyl diphosphate synthase	ENSG00000160752	FDPS	chr1:155308748-155320666:+	Tclin	281.708
trefoil factor 1	ENSG00000160182	TFF1	chr21:42362282-42366594:-	Tbio	353.625
xanthine dehydrogenase	ENSG00000158125	XDH	chr2:31334321-31414715:-	Tclin	823.556
syndecan 2	ENSG00000169439	SDC2	chr8:96493351-96611780:+	Tbio	297.683
ATP binding cassette subfamily C member 11	ENSG00000121270	ABCC11	chr16:48166910-48247568:-	Tbio	86.6377
nei like DNA glycosylase 3	ENSG00000109674	NEIL3	chr4:177309836-177362943:+	Tbio	41.6657
protein kinase cAMP-dependent type I regulatory subunit alpha	ENSG00000108946	PRKAR1A	chr17:68511780-68551319:+	Tbio	263.192
matrix metallopeptidase 2	ENSG00000087245	MMP2	chr16:55389700-55506691:+	Tchem	4473.48
aquaporin 4	ENSG00000171885	AQP4	chr18:26852038-26865818:-	Tbio	1223.42
egl-9 family hypoxia inducible factor 1	ENSG00000135766	EGLN1	chr1:231363751-231425044:-	Tchem	210.664
nicotinamide phosphoribosyltransferase	ENSG00000105835	NAMPT	chr7:106248285-106286326:-	Tchem	881.14

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