PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
serine protease 12ENSG00000164099PRSS12chr4:118280038-118353003:-Tbio12.0876
Fc receptor like 4ENSG00000163518FCRL4chr1:157573749-157598080:-Tbio23.9393
solute carrier family 25 member 12ENSG00000115840SLC25A12chr2:171784370-171999859:-Tbio49.0749
phospholipase A2 group XIIAENSG00000123739PLA2G12Achr4:109709989-109730077:-Tbio7.27944
retinoid X receptor betaENSG00000204231RXRBchr6:33193588-33200688:-Tclin82.2537
interleukin 9ENSG00000145839IL9chr5:135892246-135895827:-Tbio870.988
ribosomal oxygenase 1ENSG00000170468C14orf169chr14:73490964-73493392:+Tbio9.61071
solute carrier family 12 member 9ENSG00000146828SLC12A9chr7:100826820-100867009:+Tdark4.80311
olfactory receptor family 10 subfamily R member 2ENSG00000198965OR10R2chr1:158479878-158480885:+Tdark220.86
tubulin beta 8BENSG00000173213TUBB8P12chr18:47221-73545:-Tdark0
hydroxysteroid dehydrogenase like 2ENSG00000119471HSDL2chr9:112379937-112472410:+Tdark3
C-C motif chemokine ligand 3 like 3ENSG00000276085CCL3L3chr17:36194869-36196758:-0
arginyl aminopeptidase like 1ENSG00000142327RNPEPL1chr2:240565804-240581372:+Tbio1.33333
cripto, FRL-1, cryptic family 1ENSG00000136698CFC1chr2:130592168-130599575:-Tbio810.339
interferon alpha 17ENSG00000234829IFNA17chr9:21206528-21228222:-Tbio220.983
integrator complex subunit 12ENSG00000138785INTS12chr4:105682627-105895986:-Tbio4.78333
CDC42 binding protein kinase betaENSG00000198752CDC42BPBchr14:102932379-103057462:-Tbio9.55278
rhomboid like 3ENSG00000141314RHBDL3chr17:32266176-32324661:+Tdark5.2
myotubularin related protein 1ENSG00000063601MTMR1chrX:150692971-150765103:+Tbio6.57738
crystallin zeta like 1ENSG00000205758CRYZL1chr21:33589341-33643926:-Tbio2

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