PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
tachykinin receptor 3ENSG00000169836TACR3chr4:103586031-103719816:-Tchem127.214
interleukin 22ENSG00000127318IL22chr12:68248242-68253607:-Tbio492.264
NME/NM23 family member 8ENSG00000086288NME8chr7:37848597-37900401:+Tbio10.5125
testis associated actin remodelling kinase 1ENSG00000107140TESK1chr9:35605305-35610041:+Tbio8.86607
chymotrypsin likeENSG00000141086CTRLchr16:67927640-67932414:-Tchem80.5099
R3H domain containing likeENSG00000101074R3HDMLchr20:44336986-44351235:+Tdark0.5
BAH domain and coiled-coil containing 1ENSG00000266074BAHCC1chr17:81395475-81466332:+Tbio0.666666
valosin containing protein lysine methyltransferaseENSG00000100483VCPKMTchr14:50108632-50116600:-Tbio1.7
complement C1q B chainENSG00000173369C1QBchr1:22652762-22661538:+Tbio22.5805
Nedd4 family interacting protein 1ENSG00000131507NDFIP1chr5:142108505-142154443:+Tbio10.0274
branched chain keto acid dehydrogenase kinaseENSG00000103507BCKDKchr16:31106107-31112791:+Tbio16.7417
solute carrier family 25 member 1ENSG00000100075SLC25A1chr22:19175575-19178830:-Tbio44.7139
neuroligin 4 Y-linkedENSG00000165246NLGN4YchrY:14522638-14845650:+Tbio2.06111
solute carrier family 9 member A6ENSG00000198689SLC9A6chrX:135985424-136047269:+Tbio66.1987
5-hydroxytryptamine receptor 1AENSG00000178394HTR1Achr5:63960356-63962507:-Tclin2166.02
dehydrogenase/reductase 11ENSG00000278535DHRS11chr17:36591798-36600806:+Tbio0.5
G protein-coupled receptor 25ENSG00000170128GPR25chr1:200873038-200874123:+Tdark2.32143
potassium voltage-gated channel subfamily H member 5ENSG00000140015KCNH5chr14:62699454-63102037:-Tclin17.9118
UDP glucuronosyltransferase family 1 member A7ENSG00000244122UGT1A7chr2:233681938-233773299:+Tbio110.22
two pore segment channel 1ENSG00000186815TPCN1chr12:113221050-113298585:+Tbio87.6612

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