PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| tubulin beta 1 class VI | ENSG00000101162 | TUBB1 | chr20:59019254-59026654:+ | Tclin | 13.9785 |
| multiple inositol-polyphosphate phosphatase 1 | ENSG00000107789 | MINPP1 | chr10:87504875-87553460:+ | Tbio | 20.3429 |
| serine protease 53 | ENSG00000151006 | PRSS53 | chr16:31083425-31089628:- | Tdark | 3.16667 |
| kelch like family member 21 | ENSG00000162413 | KLHL21 | chr1:6590724-6614607:- | Tbio | 0.2 |
| interleukin 17 receptor C | ENSG00000163702 | IL17RC | chr3:9917074-9933630:+ | Tclin | 24.913 |
| serine/threonine kinase 19 | ENSG00000204344 | STK19 | chr6:31971091-31982821:+ | Tbio | 86.8604 |
| spindlin 1 | ENSG00000106723 | SPIN1 | chr9:88388419-88478694:+ | Tbio | 3749.06 |
| zinc finger RANBP2-type containing 2 | ENSG00000132485 | ZRANB2 | chr1:71063291-71081297:- | Tbio | 20.4305 |
| NIMA related kinase 4 | ENSG00000114904 | NEK4 | chr3:52708449-52770949:- | Tbio | 12.9889 |
| NIMA related kinase 9 | ENSG00000119638 | NEK9 | chr14:75079353-75127344:- | Tchem | 18.4842 |
| TUB like protein 1 | ENSG00000112041 | TULP1 | chr6:35497874-35512938:- | Tbio | 45.8446 |
| bromodomain containing 3 | ENSG00000169925 | BRD3 | chr9:134030305-134068535:- | Tchem | 25.1783 |
| solute carrier family 11 member 2 | ENSG00000110911 | SLC11A2 | chr12:50979401-51028566:- | Tchem | 237.172 |
| CEA cell adhesion molecule 3 | ENSG00000170956 | CEACAM3 | chr19:41796437-41811553:+ | Tbio | 8281.31 |
| thioredoxin related transmembrane protein 3 | ENSG00000166479 | TMX3 | chr18:68673688-68715298:- | Tbio | 6.59167 |
| neuropeptide S | ENSG00000214285 | NPS | chr10:127549369-127552639:+ | Tbio | 35.45 |
| bromodomain containing 7 | ENSG00000166164 | BRD7 | chr16:50313487-50368934:- | Tchem | 39.9591 |
| cholecystokinin A receptor | ENSG00000163394 | CCKAR | chr4:26481400-26490462:- | Tclin | 256.249 |
| adenylate cyclase 6 | ENSG00000174233 | ADCY6 | chr12:48766194-48789037:- | Tbio | 40.7576 |
| aldehyde dehydrogenase 16 family member A1 | ENSG00000161618 | ALDH16A1 | chr19:49453169-49471048:+ | Tdark | 2.33333 |
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