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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
OCRL inositol polyphosphate-5-phosphatase	ENSG00000122126	OCRL	chrX:129539849-129592561:+	Tbio	162.623
serpin family A member 9	ENSG00000170054	SERPINA9	chr14:94462717-94479689:-	Tbio	21.3507
tripartite motif containing 4	ENSG00000146833	TRIM4	chr7:99876958-99919600:-	Tdark	3.43716
calmodulin 2	ENSG00000143933	CALM2	chr2:47160082-47176601:-		0
microtubule associated serine/threonine kinase 3	ENSG00000099308	MAST3	chr19:18097793-18151692:+	Tbio	5.44286
chromodomain helicase DNA binding protein 8	ENSG00000100888	CHD8	chr14:21385194-21456126:-	Tbio	35.4516
maltase-glucoamylase 2 (putative)	ENSG00000257743	MGAM2	chr7:142111749-142222324:+	Tdark	0
nemo like kinase	ENSG00000087095	NLK	chr17:28041737-28196381:+	Tchem	56.1346
solute carrier family 23 member 3	ENSG00000213901	SLC23A3	chr2:219161465-219170095:-	Tdark	2.18333
proteoglycan 2, pro eosinophil major basic protein	ENSG00000186652	PRG2	chr11:57386794-57390657:-	Tbio	164.301
solute carrier organic anion transporter family member 3A1	ENSG00000176463	SLCO3A1	chr15:91853695-92172435:+	Tbio	17.3867
aldo-keto reductase family 1 member D1	ENSG00000122787	AKR1D1	chr7:138002324-138117986:+	Tbio	51.8845
spindlin family member 2B	ENSG00000186787	SPIN2B	chrX:57118551-57121547:-	Tdark	0.5
Scm polycomb group protein homolog 1	ENSG00000010803	SCMH1	chr1:41027200-41242154:-	Tdark	2.8193
lipocalin 1	ENSG00000160349	LCN1	chr9:135521438-135526532:+	Tbio	99.0833
melatonin receptor 1B	ENSG00000134640	MTNR1B	chr11:92969720-92985066:+	Tclin	153.092
thiosulfate sulfurtransferase like domain containing 2	ENSG00000136925	TSTD2	chr9:97600080-97633575:-	Tdark	0
potassium voltage-gated channel modifier subfamily G member 4	ENSG00000168418	KCNG4	chr16:84218667-84239750:-	Tclin	4.95
NIMA related kinase 5	ENSG00000197168	NEK5	chr13:52033611-52129078:-	Tchem	2.00263
FMRP translational regulator 1	ENSG00000102081	FMR1	chrX:147911951-147951125:+	Tbio	1941.32

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