PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
dehydrogenase/reductase 4ENSG00000157326DHRS4chr14:23953586-23969279:+Tbio25.075
apoptosis inducing factor mitochondria associated 2ENSG00000042286AIFM2chr10:70098223-70132934:-Tbio13.2778
inhibin subunit beta CENSG00000175189INHBCchr12:57434760-57450828:+Tbio9.70092
solute carrier family 25 member 11ENSG00000108528SLC25A11chr17:4937130-4940251:-Tbio25.7047
solute carrier family 25 member 35ENSG00000125434SLC25A35chr17:8287763-8295343:-Tdark0.398352
protein tyrosine phosphatase non-receptor type 20ENSG00000204179PTPN20chr10:46911396-47002488:+Tdark1.14286
nardilysin convertaseENSG00000078618NRD1chr1:51789191-51878937:-Tbio34.881
tubulointerstitial nephritis antigen like 1ENSG00000142910TINAGL1chr1:31576485-31587686:+Tbio6.82593
interleukin 20 receptor subunit alphaENSG00000016402IL20RAchr6:136999971-137045180:-Tbio17.118
SEC11 homolog C, signal peptidase complex subunitENSG00000166562SEC11Cchr18:59139477-59158836:+Tdark1.34286
relaxin family peptide receptor 2ENSG00000133105RXFP2chr13:31739542-31803388:+Tbio72.955
solute carrier family 17 member 4ENSG00000146039SLC17A4chr6:25754699-25781191:+Tdark4.97619
solute carrier family 9 member B1ENSG00000164037SLC9B1chr4:102885048-103019739:-Tbio15.5
chondroitin sulfate synthase 1ENSG00000131873CHSY1chr15:101175723-101251932:-Tbio31.6595
prokineticin receptor 1ENSG00000169618PROKR1chr2:68643589-68658247:+Tchem23.9456
splA/ryanodine receptor domain and SOCS box containing 2ENSG00000111671SPSB2chr12:6870935-6889358:-Tbio7.40788
solute carrier family 27 member 1ENSG00000130304SLC27A1chr19:17468769-17506168:+Tchem65.8709
euchromatic histone lysine methyltransferase 2ENSG00000204371EHMT2chr6:31879759-31897687:-Tchem129.252
ADAM metallopeptidase domain 18ENSG00000168619ADAM18chr8:39584489-39730064:+Tdark5.2
WAP four-disulfide core domain 12ENSG00000168703WFDC12chr20:45123425-45124465:-Tbio1.18373

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