PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
napsin B aspartic peptidase, pseudogeneENSG00000131401NAPSBchr19:50333796-50344767:-0
taste 2 receptor member 43ENSG00000255374TAS2R43chr12:11091287-11134244:-Tbio6.43333
X-prolyl aminopeptidase 1ENSG00000108039XPNPEP1chr10:109864766-109923553:-Tbio48.7748
complement factor H related 3ENSG00000116785CFHR3chr1:196774795-196795406:+Tbio32.9238
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7ENSG00000099377HSD3B7chr16:30985207-30989152:+Tbio16.45
chromobox 6ENSG00000183741CBX6chr22:38861450-38872314:-Tchem1.225
cysteine sulfinic acid decarboxylaseENSG00000139631CSADchr12:53157663-53180909:-Tbio33.7095
phospholipase C eta 2ENSG00000149527PLCH2chr1:2425980-2505530:+Tbio7.73809
NIMA related kinase 10ENSG00000163491NEK10chr3:27110085-27369460:-Tdark2.70278
amelogenin X-linkedENSG00000125363AMELXchrX:11293413-11300761:+Tbio189.908
FKBP prolyl isomerase 9ENSG00000122642FKBP9chr7:32957404-33006931:+Tdark8.05952
thioredoxin domain containing 9ENSG00000115514TXNDC9chr2:99318982-99340702:-Tbio8.64286
solute carrier family 41 member 2ENSG00000136052SLC41A2chr12:104802553-104958744:-Tdark1.99058
lysine acetyltransferase 2AENSG00000108773KAT2Achr17:42113108-42121358:-Tbio146.99
FLVCR heme transporter 2ENSG00000119686FLVCR2chr14:75578617-75663214:+Tbio12.5333
ATPase plasma membrane Ca2+ transporting 1ENSG00000070961ATP2B1chr12:89588049-89709300:-Tbio67.063
solute carrier family 46 member 3ENSG00000139508SLC46A3chr13:28700064-28718970:-Tdark0.5
N-myristoyltransferase 2ENSG00000152465NMT2chr10:15102584-15168693:-Tchem12.1909
LY6/PLAUR domain containing 6ENSG00000187123LYPD6chr2:149329985-149474148:+Tbio1.99286
solute carrier family 30 member 3ENSG00000115194SLC30A3chr2:27253684-27275817:-Tbio26.2468

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