PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
taspase 1ENSG00000089123TASP1chr20:13389392-13638940:-Tbio16.4715
2,4-dienoyl-CoA reductase 2ENSG00000242612DECR2chr16:401826-412487:+Tbio4.2
serpin family B member 6ENSG00000124570SERPINB6chr6:2948159-2972165:-Tbio48.3317
protein arginine methyltransferase 2ENSG00000160310PRMT2chr21:46635167-46665124:+Tbio12.9966
tudor domain containing 9ENSG00000156414TDRD9chr14:103928462-104052667:+Tbio0.958333
solute carrier family 27 member 3ENSG00000143554SLC27A3chr1:153774354-153780157:+Tbio7.58665
major facilitator superfamily domain containing 1ENSG00000118855MFSD1chr3:158732198-158829719:+Tdark0.276923
neuroplastinENSG00000156642NPTNchr15:73560014-73634134:-Tbio93.5956
attractinENSG00000088812ATRNchr20:3471040-3651122:+Tbio40.8218
ATPase H+ transporting V1 subunit G3ENSG00000151418ATP6V1G3chr1:198523222-198540945:-Tbio1.77619
poly(ADP-ribose) polymerase family member 4ENSG00000102699PARP4chr13:24420926-24512810:-Tchem24.352
tudor domain containing 3ENSG00000083544TDRD3chr13:60396457-60573878:+Tbio4.25
ER degradation enhancing alpha-mannosidase like protein 2ENSG00000088298EDEM2chr20:35115357-35147364:-Tbio6.66071
trace amine associated receptor 1ENSG00000146399TAAR1chr6:132644984-132646003:-Tclin124.372
oxidoreductase NAD binding domain containing 1ENSG00000154814OXNAD1chr3:16265160-16350299:+Tdark0.333333
catechol-O-methyltransferase domain containing 1ENSG00000165644COMTD1chr10:75233969-75236030:-Tdark0.5
guanylate cyclase 1 soluble subunit beta 1ENSG00000061918GUCY1B3chr4:155758992-155807591:+Tclin3.09121
hydroxysteroid 17-beta dehydrogenase 8ENSG00000204228HSD17B8chr6:33204642-33206831:+Tbio18.2809
PR/SET domain 5ENSG00000138738PRDM5chr4:120684919-120922870:-Tbio22.9024
ATPase phospholipid transporting 11B (putative)ENSG00000058063ATP11Bchr3:182793500-182921635:+Tbio4.27778

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