PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
dentin sialophosphoproteinENSG00000152591DSPPchr4:87608529-87616910:+Tbio249.868
microsomal glutathione S-transferase 3ENSG00000143198MGST3chr1:165630861-165661796:+Tbio11.4213
calcium voltage-gated channel auxiliary subunit alpha2delta 4ENSG00000151062CACNA2D4chr12:1791957-1918836:-Tbio7.3921
receptor like tyrosine kinaseENSG00000163785RYKchr3:134065303-134250744:-Tbio33.6561
leucine aminopeptidase 3ENSG00000002549LAP3chr4:17577192-17607972:+Tchem122.37
NIMA related kinase 7ENSG00000151414NEK7chr1:198156963-198322420:+Tchem18.227
interleukin 17FENSG00000112116IL17Fchr6:52236681-52244537:-Tbio907.803
solute carrier family 48 member 1ENSG00000211584SLC48A1chr12:47753916-47782753:+Tbio8.66021
mitochondrial trans-2-enoyl-CoA reductaseENSG00000116353MECRchr1:29192873-29230942:-Tbio9.76667
adenosylhomocysteinase like 1ENSG00000168710AHCYL1chr1:109984686-110023741:+Tchem26.8625
ER membrane protein complex subunit 10ENSG00000161671EMC10chr19:50476400-50490870:+Tbio6.70757
calcium/calmodulin dependent protein kinase IDENSG00000183049CAMK1Dchr10:12349482-12835545:+Tchem15.4511
potassium voltage-gated channel subfamily D member 1ENSG00000102057KCND1chrX:48961378-48971569:-Tclin14.646
C-type lectin domain containing 14AENSG00000176435CLEC14Achr14:38254103-38256369:-Tbio19.4178
ATP binding cassette subfamily D member 4ENSG00000119688ABCD4chr14:74285423-74303056:-Tbio13.1376
G protein-coupled receptor 171ENSG00000174946GPR171chr3:151197832-151203201:-Tdark0.79881
bleomycin hydrolaseENSG00000108578BLMHchr17:30248195-30292056:-Tbio71.1922
solute carrier family 25 member 29ENSG00000197119SLC25A29chr14:100291111-100306547:-Tbio9.79545
SET domain containing 6, protein lysine methyltransferaseENSG00000103037SETD6chr16:58515479-58521181:+Tbio3.86111
mitogen-activated protein kinase kinase kinase 6ENSG00000142733MAP3K6chr1:27355184-27366892:-Tbio12.5262

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