PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| erythroblast membrane associated protein (Scianna blood group) | ENSG00000164010 | ERMAP | chr1:42817124-42844989:+ | Tbio | 13.3333 |
| CDC like kinase 3 | ENSG00000179335 | CLK3 | chr15:74598500-74645414:+ | Tchem | 8.38889 |
| biphenyl hydrolase like | ENSG00000137274 | BPHL | chr6:3118374-3153578:+ | Tbio | 18.5667 |
| protein kinase D3 | ENSG00000115825 | PRKD3 | chr2:37250502-37324808:- | Tchem | 13.983 |
| crystallin zeta | ENSG00000116791 | CRYZ | chr1:74705482-74733408:- | Tbio | 30.2417 |
| lysine methyltransferase 2B | ENSG00000272333 | KMT2B | chr19:35718019-35738878:+ | Tbio | 38.1599 |
| adhesion G protein-coupled receptor G2 | ENSG00000173698 | ADGRG2 | chrX:18989309-19122637:- | Tbio | 13.2482 |
| mutL homolog 3 | ENSG00000119684 | MLH3 | chr14:75013764-75051532:- | Tbio | 40.5821 |
| gamma-aminobutyric acid type A receptor subunit alpha2 | ENSG00000151834 | GABRA2 | chr4:46248427-46475230:- | Tclin | 112.395 |
| inositol monophosphatase 2 | ENSG00000141401 | IMPA2 | chr18:11981025-12030883:+ | Tbio | 45.3358 |
| lipase H | ENSG00000163898 | LIPH | chr3:185506262-185552613:- | Tbio | 64.0885 |
| odr-4 GPCR localization factor homolog | ENSG00000157181 | C1orf27 | chr1:186375758-186421378:+ | Tdark | 4.08333 |
| gastrokine 2 | ENSG00000183607 | GKN2 | chr2:68945232-68952970:- | Tbio | 14.7282 |
| hydroxysteroid 17-beta dehydrogenase 11 | ENSG00000198189 | HSD17B11 | chr4:87336610-87391386:- | Tbio | 9.44167 |
| aminopeptidase like 1 | ENSG00000215440 | NPEPL1 | chr20:58689131-58719238:+ | Tdark | 0.638889 |
| ribosomal oxygenase 2 | ENSG00000170854 | MINA | chr3:97941818-97972457:- | Tbio | 49.9583 |
| inhibitor of growth family member 2 | ENSG00000168556 | ING2 | chr4:183504994-183511096:+ | Tbio | 827.929 |
| follicle stimulating hormone subunit beta | ENSG00000131808 | FSHB | chr11:30231016-30235261:+ | Tbio | 290.656 |
| A-kinase anchoring protein 1 | ENSG00000121057 | AKAP1 | chr17:57085092-57121349:+ | Tbio | 148.381 |
| DAN domain BMP antagonist family member 5 | ENSG00000179284 | DAND5 | chr19:12965159-12974762:+ | Tbio | 52.1102 |
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