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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
arginine vasopressin receptor 1B	ENSG00000198049	AVPR1B	chr1:206109692-206117699:-	Tclin	32.169
TGF-beta activated kinase 1 (MAP3K7) binding protein 1	ENSG00000100324	TAB1	chr22:39399741-39437060:+	Tbio	19.1935
mucin 7, secreted	ENSG00000171195	MUC7	chr4:70430492-70482997:+	Tbio	900.835
L3MBTL histone methyl-lysine binding protein 2	ENSG00000100395	L3MBTL2	chr22:41205205-41231271:+	Tbio	6.72619
thioredoxin reductase 3	ENSG00000197763	TXNRD3	chr3:126571779-126655155:-	Tdark	1
natural cytotoxicity triggering receptor 1	ENSG00000189430	NCR1	chr19:54906150-54916140:+	Tbio	166.532
hydroxysteroid 17-beta dehydrogenase 3	ENSG00000130948	HSD17B3	chr9:96235306-96302152:-	Tchem	61.1566
carnitine O-acetyltransferase	ENSG00000095321	CRAT	chr9:129094810-129111189:-	Tbio	127.265
protein disulfide isomerase family A member 5	ENSG00000065485	PDIA5	chr3:123067062-123225227:+	Tbio	6.30952
solute carrier organic anion transporter family member 1C1	ENSG00000139155	SLCO1C1	chr12:20695355-20753386:+	Tbio	26.254
solute carrier family 26 member 11	ENSG00000181045	SLC26A11	chr17:80219699-80253500:+	Tdark	6.6
solute carrier family 26 member 9	ENSG00000174502	SLC26A9	chr1:205913048-205943460:-	Tbio	15.5429
phospholipase B domain containing 1	ENSG00000121316	PLBD1	chr12:14503661-14568349:-	Tdark	0.359524
cholinergic receptor muscarinic 4	ENSG00000180720	CHRM4	chr11:46385098-46386608:-	Tclin	43.7504
solute carrier family 16 member 14	ENSG00000163053	SLC16A14	chr2:230034974-230068999:-	Tdark	2.09286
solute carrier family 35 member C2	ENSG00000080189	SLC35C2	chr20:46345980-46364458:-	Tdark	5.14286
rhomboid domain containing 1	ENSG00000144468	RHBDD1	chr2:226835581-226999215:+	Tbio	7.98874
chloride voltage-gated channel 4	ENSG00000073464	CLCN4	chrX:10156945-10237660:+	Tbio	29.9707
signal peptide peptidase like 2B	ENSG00000005206	SPPL2B	chr19:2328615-2354806:+	Tbio	17.2012
protein serine kinase H1	ENSG00000159792	PSKH1	chr16:67893272-67929678:+	Tdark	6.4

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