PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| ATPase H+ transporting V0 subunit e2 | ENSG00000171130 | ATP6V0E2 | chr7:149872968-149880698:+ | Tdark | 2.5 |
| FKBP prolyl isomerase 14 | ENSG00000106080 | FKBP14 | chr7:30010587-30026684:- | Tbio | 13.3476 |
| solute carrier family 35 member F6 | ENSG00000213699 | SLC35F6 | chr2:26764284-26781231:+ | Tbio | 1.33333 |
| cerebellin 3 precursor | ENSG00000139899 | CBLN3 | chr14:24426532-24430954:- | Tdark | 0.416667 |
| tubulin alpha 4a | ENSG00000127824 | TUBA4A | chr2:219249711-219278170:- | Tchem | 28.1274 |
| immunoglobulin superfamily containing leucine rich repeat 2 | ENSG00000167178 | ISLR2 | chr15:74100311-74138540:+ | Tbio | 33.95 |
| solute carrier family 44 member 2 | ENSG00000129353 | SLC44A2 | chr19:10602457-10644559:+ | Tbio | 39.2036 |
| kelch like family member 7 | ENSG00000122550 | KLHL7 | chr7:23105758-23177914:+ | Tbio | 9.11237 |
| endoplasmic reticulum protein 29 | ENSG00000089248 | ERP29 | chr12:112013316-112023451:+ | Tbio | 52.1603 |
| ADAM metallopeptidase with thrombospondin type 1 motif 19 | ENSG00000145808 | ADAMTS19 | chr5:129460265-129738683:+ | Tbio | 2.93968 |
| solute carrier family 4 member 8 | ENSG00000050438 | SLC4A8 | chr12:51391317-51515763:+ | Tbio | 13.2841 |
| inhibitor of growth family member 4 | ENSG00000111653 | ING4 | chr12:6650280-6663148:- | Tbio | 87.9614 |
| potassium voltage-gated channel subfamily A member 1 | ENSG00000111262 | KCNA1 | chr12:4909905-4931361:+ | Tclin | 306.361 |
| TMEM9 domain family member B | ENSG00000175348 | TMEM9B | chr11:8947294-8965011:- | Tdark | 1.33333 |
| SP100 nuclear antigen | ENSG00000067066 | SP100 | chr2:230415942-230544090:+ | Tbio | 128.273 |
| taste 1 receptor member 3 | ENSG00000169962 | TAS1R3 | chr1:1331314-1335306:+ | Tbio | 75.2046 |
| butyrophilin subfamily 3 member A2 | ENSG00000186470 | BTN3A2 | chr6:26365159-26378320:+ | Tbio | 13.097 |
| solute carrier family 9 member A4 | ENSG00000180251 | SLC9A4 | chr2:102473303-102533972:+ | Tdark | 8.61667 |
| OMA1 zinc metallopeptidase | ENSG00000162600 | OMA1 | chr1:58415384-58546802:- | Tbio | 11.0298 |
| phosphodiesterase 6D | ENSG00000156973 | PDE6D | chr2:231732425-231786272:- | Tclin | 9.52702 |
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