PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
protein prenyltransferase alpha subunit repeat containing 1ENSG00000188647PTAR1chr9:69709522-69759959:-Tdark0
glycine receptor betaENSG00000109738GLRBchr4:157076057-157172090:+Tclin29.8167
odorant binding protein 2BENSG00000171102OBP2Bchr9:133205277-133209250:-Tdark2.16667
glycoprotein IX plateletENSG00000169704GP9chr3:129060767-129062406:+Tbio121.783
carboxypeptidase A2ENSG00000158516CPA2chr7:130266827-130289798:+Tbio30.1282
peptidoglycan recognition protein 1ENSG00000008438PGLYRP1chr19:46019153-46023065:-Tbio69.7663
solute carrier family 49 member 3ENSG00000169026MFSD7chr4:681829-689441:-Tdark0.342857
protein kinase cAMP-dependent type II regulatory subunit alphaENSG00000114302PRKAR2Achr3:48744597-48847846:-Tbio6.59405
von Willebrand factor A domain containing 1ENSG00000179403VWA1chr1:1434861-1442882:+Tbio13.8929
defensin beta 126ENSG00000125788DEFB126chr20:142369-145751:+Tbio10.0864
kelch like family member 18ENSG00000114648KLHL18chr3:47282917-47346816:+Tdark0.392857
BCL2 family apoptosis regulator BOKENSG00000176720BOKchr2:241558721-241574138:+Tbio65.5305
serpin family A member 10ENSG00000140093SERPINA10chr14:94280455-94293271:-Tbio52.269
solute carrier family 10 member 5ENSG00000253598SLC10A5chr8:81693607-81696174:-Tdark102.891
peroxidasin likeENSG00000147485PXDNLchr8:51319578-51809445:-Tbio8.51624
SRSF protein kinase 2ENSG00000135250SRPK2chr7:105110704-105399308:-Tchem15.7762
potassium two pore domain channel subfamily K member 17ENSG00000124780KCNK17chr6:39299001-39314553:-Tbio38.6218
neuroligin 4 X-linkedENSG00000146938NLGN4XchrX:5840637-6228863:-Tbio41.0746
C-C motif chemokine ligand 16ENSG00000275152CCL16chr17:35976493-35981496:-Tbio141.255
apolipoprotein A5ENSG00000110243APOA5chr11:116789367-116792420:-Tbio510.961

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