PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| solute carrier family 25 member 16 | ENSG00000122912 | SLC25A16 | chr10:68477999-68527474:- | Tbio | 87.7855 |
| kelch like family member 2 | ENSG00000109466 | KLHL2 | chr4:165207618-165323156:+ | Tbio | 20.1726 |
| N-sulfoglucosamine sulfohydrolase | ENSG00000181523 | SGSH | chr17:80206716-80220923:- | Tbio | 81.3667 |
| ubiquitin specific peptidase 30 | ENSG00000135093 | USP30 | chr12:109023089-109088026:+ | Tbio | 13.9278 |
| olfactory receptor family 2 subfamily B member 6 | ENSG00000124657 | OR2B6 | chr6:27957241-27958182:+ | Tdark | 8.08333 |
| gamma-aminobutyric acid type A receptor subunit alpha5 | ENSG00000186297 | GABRA5 | chr15:26866363-26949207:+ | Tclin | 34.5579 |
| DnaJ heat shock protein family (Hsp40) member B11 | ENSG00000090520 | DNAJB11 | chr3:186567403-186597203:+ | Tbio | 21.3267 |
| uromodulin like 1 | ENSG00000177398 | UMODL1 | chr21:42062959-42143453:+ | Tdark | 6.9 |
| mannose-6-phosphate receptor, cation dependent | ENSG00000003056 | M6PR | chr12:8940363-8949955:- | Tbio | 118.278 |
| L3MBTL histone methyl-lysine binding protein 3 | ENSG00000198945 | L3MBTL3 | chr6:130013699-130141451:+ | Tchem | 5.71111 |
| solute carrier family 7 member 10 | ENSG00000130876 | SLC7A10 | chr19:33208664-33225850:- | Tbio | 35.2369 |
| lactase like | ENSG00000188501 | LCTL | chr15:66547179-66565979:- | Tdark | 2.66667 |
| ATPase 13A3 | ENSG00000133657 | ATP13A3 | chr3:194402672-194498364:- | Tdark | 3.14286 |
| kelch like family member 5 | ENSG00000109790 | KLHL5 | chr4:39045039-39126857:+ | Tdark | 2.66667 |
| SLIT and NTRK like family member 4 | ENSG00000179542 | SLITRK4 | chrX:143622790-143635777:- | Tbio | 2.44444 |
| eukaryotic translation initiation factor 4H | ENSG00000106682 | EIF4H | chr7:74174245-74197101:+ | Tchem | 22.0417 |
| vesicle associated membrane protein 8 | ENSG00000118640 | VAMP8 | chr2:85561562-85582031:+ | Tbio | 104.032 |
| leucine rich repeat containing 4B | ENSG00000131409 | LRRC4B | chr19:50516892-50568045:- | Tdark | 2.58333 |
| FKBP prolyl isomerase 3 | ENSG00000100442 | FKBP3 | chr14:45115600-45135319:- | Tbio | 35.3806 |
| sodium voltage-gated channel alpha subunit 11 | ENSG00000168356 | SCN11A | chr3:38845769-38950561:- | Tclin | 153.927 |
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