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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
opioid receptor mu 1	ENSG00000112038	OPRM1	chr6:154010496-154246867:+	Tclin	1271.57
sphingomyelin phosphodiesterase 4	ENSG00000136699	SMPD4	chr2:130151392-130182750:-	Tbio	3.33333
interleukin 17C	ENSG00000124391	IL17C	chr16:88638591-88640473:+	Tbio	48.2801
potassium inwardly rectifying channel subfamily J member 9	ENSG00000162728	KCNJ9	chr1:160081570-160090563:+	Tbio	16.3167
solute carrier family 25 member 43	ENSG00000077713	SLC25A43	chrX:119399060-119454478:+	Tdark	6.01502
activin A receptor type 1B	ENSG00000135503	ACVR1B	chr12:51951667-51997078:+	Tchem	61.6197
cysteine rich transmembrane BMP regulator 1	ENSG00000150938	CRIM1	chr2:36355926-36551135:+	Tbio	18.3825
Scm like with four mbt domains 1	ENSG00000163935	SFMBT1	chr3:52903572-53046750:-	Tbio	52.2054
phospholipase A1 member A	ENSG00000144837	PLA1A	chr3:119597842-119629811:+	Tbio	11.6623
H3 clustered histone 6	ENSG00000274750	HIST1H3E	chr6:26225155-26225565:+		0
kelch like family member 23	ENSG00000213160	KLHL23	chr2:169694488-169776989:+	Tdark	1.14286
dual specificity tyrosine phosphorylation regulated kinase 4	ENSG00000010219	DYRK4	chr12:4562204-4615302:+	Tdark	2.21667
solute carrier family 35 member E2A	ENSG00000215790	SLC35E2	chr1:1724838-1745992:-	Tdark	0
potassium voltage-gated channel modifier subfamily V member 2	ENSG00000168263	KCNV2	chr9:2717502-2730037:+	Tclin	45.8301
otoraplin	ENSG00000125879	OTOR	chr20:16748358-16770062:+	Tbio	62.9262
ATP/GTP binding protein 1	ENSG00000135049	AGTPBP1	chr9:85546539-85742029:-	Tbio	10.8383
solute carrier family 35 member C1	ENSG00000181830	SLC35C1	chr11:45804072-45813015:+	Tbio	10.2429
TAO kinase 3	ENSG00000135090	TAOK3	chr12:118149801-118372945:-	Tchem	27.2967
kelch like family member 28	ENSG00000179454	KLHL28	chr14:44924319-45042322:-	Tdark	0
adhesion G protein-coupled receptor G7	ENSG00000144820	ADGRG7	chr3:100609589-100695479:+	Tdark	1.60055

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