PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
bactericidal permeability increasing proteinENSG00000101425BPIchr20:38260149-38337505:+Tbio416.577
slingshot protein phosphatase 1ENSG00000084112SSH1chr12:108778192-108857590:-Tbio34.8929
papilin, proteoglycan like sulfated glycoproteinENSG00000100767PAPLNchr14:73237497-73274640:+Tbio1.01111
peptidylprolyl isomerase DENSG00000171497PPIDchr4:158709134-158723396:-Tchem105.719
calcium voltage-gated channel subunit alpha1 SENSG00000081248CACNA1Schr1:201039512-201112566:-Tclin218.753
CD300 molecule like family member bENSG00000178789CD300LBchr17:74521174-74531474:-Tbio4.55278
CD300e moleculeENSG00000186407CD300Echr17:74609887-74623738:-Tbio5.48718
kelch like family member 3ENSG00000146021KLHL3chr5:137617500-137736090:-Tbio13.3337
adrenoceptor beta 3ENSG00000188778ADRB3chr8:37962991-37966965:-Tclin632.851
CD164 moleculeENSG00000135535CD164chr6:109366514-109382559:-Tbio29.3222
protein kinase domain containing, cytoplasmicENSG00000162878PKDCCchr2:42048020-42058528:+Tbio3.61111
solute carrier family 15 member 3ENSG00000110446SLC15A3chr11:60937083-60952530:-Tbio8.71111
solute carrier family 37 member 2ENSG00000134955SLC37A2chr11:125063067-125090312:+Tbio2.81026
lysine acetyltransferase 7ENSG00000136504KAT7chr17:49788555-49835030:+Tbio38.9949
protein phosphatase, Mg2+/Mn2+ dependent 1BENSG00000138032PPM1Bchr2:44167969-44244384:+Tchem23.2437
solute carrier family 44 member 5ENSG00000137968SLC44A5chr1:75202131-75611116:-Tdark2.14286
RAB35, member RAS oncogene familyENSG00000111737RAB35chr12:120095095-120117502:-Tbio26.1082
nectin cell adhesion molecule 3ENSG00000177707PVRL3chr3:111070071-111275563:+Tbio22.1647
ASXL transcriptional regulator 3ENSG00000141431ASXL3chr18:33578615-33751192:+Tbio15.0817
ectonucleoside triphosphate diphosphohydrolase 6ENSG00000197586ENTPD6chr20:25195693-25226729:+Tbio7.55238

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