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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
carbohydrate sulfotransferase 2	ENSG00000175040	CHST2	chr3:143119331-143124014:+	Tbio	18.4251
growth hormone 1	ENSG00000259384	GH1	chr17:63917200-63918838:-	Tbio	270.819
carnitine O-octanoyltransferase	ENSG00000005469	CROT	chr7:87345681-87399795:+	Tbio	10.3139
prostaglandin reductase 1	ENSG00000106853	PTGR1	chr9:111549722-111599855:-	Tbio	21.25
protein tyrosine phosphatase domain containing 1	ENSG00000158079	PTPDC1	chr9:94030794-94109856:+	Tdark	0.149573
inhibitor of growth family member 1	ENSG00000153487	ING1	chr13:110712736-110723339:+	Tbio	240.266
hedgehog acyltransferase like	ENSG00000010282	HHATL	chr3:42692663-42702827:-	Tbio	0.958333
adrenoceptor alpha 1A	ENSG00000120907	ADRA1A	chr8:26748150-26867273:-	Tclin	199.681
autophagy related 4C cysteine peptidase	ENSG00000125703	ATG4C	chr1:62784135-62865513:+	Tbio	3.8913
lysine demethylase 5D	ENSG00000012817	KDM5D	chrY:19703865-19744939:-	Tbio	52.0491
SET domain containing 7, histone lysine methyltransferase	ENSG00000145391	SETD7	chr4:139495941-139606699:-	Tchem	74.965
double PHD fingers 2	ENSG00000133884	DPF2	chr11:65333754-65353249:+	Tbio	8.9798
aldehyde dehydrogenase 3 family member B1	ENSG00000006534	ALDH3B1	chr11:68008578-68029282:+	Tbio	16.5429
ankyrin repeat and kinase domain containing 1	ENSG00000170209	ANKK1	chr11:113387791-113400418:+	Tbio	112.618
anti-Mullerian hormone receptor type 2	ENSG00000135409	AMHR2	chr12:53423855-53431534:+	Tbio	61.658
thymosin beta 4 X-linked	ENSG00000205542	TMSB4X	chrX:12975108-12977227:+	Tbio	56.0333
kelch like family member 29	ENSG00000119771	KLHL29	chr2:23385217-23708611:+	Tbio	0
metastasis associated 1 family member 3	ENSG00000057935	MTA3	chr2:42494569-42756947:+	Tbio	20.932
phosphoethanolamine/phosphocholine phosphatase 1	ENSG00000173868	PHOSPHO1	chr17:49223362-49230766:-	Tchem	18.7076
taste 2 receptor member 46	ENSG00000226761	TAS2R46	chr12:11061365-11062294:-	Tbio	6.31667

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