PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
HDGF like 3ENSG00000166503HDGFRP3chr15:83112738-83208018:-Tbio9.45
3'(2'), 5'-bisphosphate nucleotidase 1ENSG00000162813BPNT1chr1:220057482-220090462:-Tbio3.03333
diacylglycerol lipase alphaENSG00000134780DAGLAchr11:61680433-61747001:+Tchem18.748
histocompatibility minor serpin domain containingENSG00000221887HMSDchr18:63949301-63981774:+Tbio1
phosphatidylinositol 4-kinase type 2 betaENSG00000038210PI4K2Bchr4:25233975-25279092:+Tbio9.67778
solute carrier family 27 member 6ENSG00000113396SLC27A6chr5:128538013-129033642:+Tbio6.8166
adenosylhomocysteinase like 2ENSG00000158467AHCYL2chr7:129225023-129430211:+Tdark1.47619
peptidylprolyl isomerase GENSG00000138398PPIGchr2:169584340-169641406:+Tchem272.92
mbt domain containing 1ENSG00000011258MBTD1chr17:51177425-51260163:-Tdark3.12778
carbonic anhydrase 10ENSG00000154975CA10chr17:51630313-52160017:-Tbio47.8429
intracisternal A particle-promoted polypeptideENSG00000197429IPPchr1:45694324-45750650:-Tdark20.0833
transient receptor potential cation channel subfamily M member 3ENSG00000083067TRPM3chr9:70529063-71446904:-Tbio55.1084
family with sequence similarity 234 member AENSG00000167930ITFG3chr16:234546-268971:+Tdark0.5
phosphodiesterase 8AENSG00000073417PDE8Achr15:84980440-85139145:+Tclin18.545
major facilitator superfamily domain containing 5ENSG00000182544MFSD5chr12:53251251-53254405:+Tdark0.69359
protein kinase X-linkedENSG00000183943PRKXchrX:3604370-3713608:-Tchem27.2373
suppressor of glucose, autophagy associated 1ENSG00000149639SOGA1chr20:36777442-36863686:-Tbio15.3095
histone acetyltransferase 1ENSG00000128708HAT1chr2:171922448-171983682:+Tbio50.4075
bromodomain and PHD finger containing 3ENSG00000096070BRPF3chr6:36196744-36232790:+Tchem0.444444
solute carrier family 25 member 41ENSG00000181240SLC25A41chr19:6426037-6433779:-Tdark0.681685

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