PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
cytochrome b5 reductase 4ENSG00000065615CYB5R4chr6:83859643-83967424:+Tbio5.15
follistatin like 4ENSG00000053108FSTL4chr5:133196455-133612564:-Tdark0.090909
mitogen-activated protein kinase kinase kinase 13ENSG00000073803MAP3K13chr3:185282941-185489097:+Tchem29.0062
solute carrier family 5 member 9ENSG00000117834SLC5A9chr1:48222685-48248644:+Tdark3.74359
carbohydrate sulfotransferase 13ENSG00000180767CHST13chr3:126524283-126543291:+Tbio1.53333
G protein-coupled receptor 174ENSG00000147138GPR174chrX:79170972-79172229:+Tchem7.99762
neural EGFL like 1ENSG00000165973NELL1chr11:20669551-21575681:+Tbio48.7279
mucolipin 3ENSG00000055732MCOLN3chr1:85018082-85048499:-Tbio19.8076
hydroxycarboxylic acid receptor 1ENSG00000196917HCAR1chr12:122726076-122730843:-Tbio20.7447
complement C1q like 2ENSG00000144119C1QL2chr2:119156243-119158889:-Tdark0.667857
myosin heavy chain 6ENSG00000197616MYH6chr14:23381990-23408277:-Tbio244.081
pyruvate dehydrogenase kinase 3ENSG00000067992PDK3chrX:24465221-24539837:+Tbio20.3844
synaptosome associated protein 23ENSG00000092531SNAP23chr15:42491233-42545356:+Tbio86.9535
lysine methyltransferase 2DENSG00000167548KMT2Dchr12:49018975-49059774:-Tbio99.9634
PHD finger protein 10ENSG00000130024PHF10chr6:169703905-169725566:-Tbio11.3029
leukotriene C4 synthaseENSG00000213316LTC4Schr5:179793980-179796647:+Tbio210.303
ATPase phospholipid transporting 10D (putative)ENSG00000145246ATP10Dchr4:47485288-47593486:+Tdark3.85
purinergic receptor P2Y11ENSG00000244165P2RY11chr19:10111538-10115372:+Tchem56.6193
Fc fragment of IgA receptorENSG00000186431FCARchr19:54874248-54890472:+Tbio197.33
protein geranylgeranyltransferase type I subunit betaENSG00000164219PGGT1Bchr5:115204012-115262872:-Tchem44.0508

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