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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
phosphoinositide-3-kinase regulatory subunit 3	ENSG00000117461	PIK3R3	chr1:46040140-46133036:-	Tbio	41.2436
neurotrophic receptor tyrosine kinase 2	ENSG00000148053	NTRK2	chr9:84668551-85027070:+	Tchem	599.997
progestagen associated endometrial protein	ENSG00000122133	PAEP	chr9:135561756-135566955:+	Tbio	886.113
Fas cell surface death receptor	ENSG00000026103	FAS	chr10:88990531-89015785:+	Tbio	1849.25
kallikrein related peptidase 6	ENSG00000167755	KLK6	chr19:50958631-50969673:-	Tbio	142.894
heparan sulfate proteoglycan 2	ENSG00000142798	HSPG2	chr1:21822245-21937297:-	Tbio	739.69
solute carrier family 45 member 2	ENSG00000164175	SLC45A2	chr5:33944616-33984730:-	Tbio	125.126
chromodomain helicase DNA binding protein 4	ENSG00000111642	CHD4	chr12:6570083-6607476:-	Tbio	60.5927
CD80 molecule	ENSG00000121594	CD80	chr3:119524293-119559602:-	Tclin	1146.76
delta like non-canonical Notch ligand 1	ENSG00000185559	DLK1	chr14:100725705-100738224:+	Tchem	448.048
intelectin 1	ENSG00000179914	ITLN1	chr1:160876539-160885170:-	Tbio	289.502
solute carrier family 45 member 3	ENSG00000158715	SLC45A3	chr1:205657851-205680459:-	Tbio	32.6534
prostaglandin-endoperoxide synthase 2	ENSG00000073756	PTGS2	chr1:186671791-186680427:-	Tclin	7000.88
cadherin 3	ENSG00000062038	CDH3	chr16:68636189-68722616:+	Tbio	150.702
collagen type V alpha 1 chain	ENSG00000130635	COL5A1	chr9:134641774-134844843:+	Tbio	161.142
bone morphogenetic protein 2	ENSG00000125845	BMP2	chr20:6767664-6780280:+	Tbio	2601.75
C-C motif chemokine receptor 7	ENSG00000126353	CCR7	chr17:40553769-40565472:-	Tbio	541.86
carbonic anhydrase 12	ENSG00000074410	CA12	chr15:63321378-63382161:-	Tclin	118.933
alcohol dehydrogenase 1B (class I), beta polypeptide	ENSG00000196616	ADH1B	chr4:99304964-99321401:-	Tclin	398.67
tyrosine kinase 2	ENSG00000105397	TYK2	chr19:10350529-10380676:-	Tclin	197.813

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