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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
potassium voltage-gated channel subfamily A regulatory beta subunit 2	ENSG00000069424	KCNAB2	chr1:5991466-6101193:+	Tbio	24.0389
glutamate ionotropic receptor NMDA type subunit 3B	ENSG00000116032	GRIN3B	chr19:1000419-1009732:+	Tclin	18.0505
solute carrier family 5 member 4	ENSG00000100191	SLC5A4	chr22:32218476-32255341:-	Tchem	21.5076
isoprenylcysteine carboxyl methyltransferase	ENSG00000116237	ICMT	chr1:6221193-6235972:-	Tchem	67.7429
pyridoxal kinase	ENSG00000160209	PDXK	chr21:43719094-43762307:+	Tbio	40.9976
H3 clustered histone 15	ENSG00000203852	HIST2H3A	chr1:149852619-149854274:+	Tbio	0.111111
membrane bound O-acyltransferase domain containing 1	ENSG00000172197	MBOAT1	chr6:20102145-20212399:-	Tdark	4.4547
neuromedin B receptor	ENSG00000135577	NMBR	chr6:142058330-142088799:-	Tchem	76.2
cobalamin binding intrinsic factor	ENSG00000134812	GIF	chr11:59829268-59845501:-	Tbio	499.583
ATPase phospholipid transporting 11C	ENSG00000101974	ATP11C	chrX:139726346-139945276:-	Tbio	5.21667
cache domain containing 1	ENSG00000158966	CACHD1	chr1:64470792-64693058:+	Tdark	0
vesicle associated membrane protein 1	ENSG00000139190	VAMP1	chr12:6462237-6470987:-	Tbio	28.5994
BCL2 like 13	ENSG00000099968	BCL2L13	chr22:17628855-17730855:+	Tbio	20.4607
chromosome 17 open reading frame 99	ENSG00000187997	C17orf99	chr17:78146353-78166177:+	Tdark	0
solute carrier family 37 member 4	ENSG00000137700	SLC37A4	chr11:119024114-119030906:-	Tchem	83.3538
sphingomyelin phosphodiesterase 2	ENSG00000135587	SMPD2	chr6:109440763-109443919:+	Tchem	91.5901
casein kinase 2 alpha 2	ENSG00000070770	CSNK2A2	chr16:58157907-58197920:-	Tchem	26.0718
potassium voltage-gated channel subfamily C member 2	ENSG00000166006	KCNC2	chr12:75040077-75209868:-	Tclin	10.8373
protein arginine methyltransferase 6	ENSG00000198890	PRMT6	chr1:107056679-107059294:+	Tchem	46.7064
secreted and transmembrane 1	ENSG00000141574	SECTM1	chr17:82321024-82334074:-	Tbio	25.1528

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