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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
carbonic anhydrase 5A	ENSG00000174990	CA5A	chr16:87881546-87936529:-	Tclin	101.418
potassium two pore domain channel subfamily K member 6	ENSG00000099337	KCNK6	chr19:38319844-38332076:+	Tbio	15.5428
tripartite motif containing 66	ENSG00000166436	TRIM66	chr11:8612037-8671866:-	Tdark	0.728822
chloride voltage-gated channel 3	ENSG00000109572	CLCN3	chr4:169612633-169723673:+	Tbio	116.832
legumain	ENSG00000100600	LGMN	chr14:92703807-92748702:-	Tchem	69.5861
capping actin protein of muscle Z-line subunit alpha 1	ENSG00000116489	CAPZA1	chr1:112619173-112671619:+	Tbio	13.5449
vasorin	ENSG00000168140	VASN	chr16:4371848-4383528:+	Tbio	9.38095
H4 clustered histone 5	ENSG00000276966	HIST1H4E	chr6:26204645-26204956:+		0
fibroblast growth factor 20	ENSG00000078579	FGF20	chr8:16992169-17002181:-	Tbio	46.9749
transglutaminase 4	ENSG00000163810	TGM4	chr3:44874608-44914990:+	Tbio	40.4999
solute carrier family 38 member 10	ENSG00000157637	SLC38A10	chr17:81245000-81295547:-	Tdark	0.5
serine protease 36	ENSG00000178226	PRSS36	chr16:31138925-31150094:-	Tbio	1.66667
H4 clustered histone 4	ENSG00000277157	HIST1H4D	chr6:26188765-26189076:-		0
latent transforming growth factor beta binding protein 4	ENSG00000090006	LTBP4	chr19:40592883-40629818:+	Tbio	25.0473
C-C motif chemokine ligand 4 like 2	ENSG00000276070	CCL4L2	chr17:36210924-36212878:+	Tbio	41.267
solute carrier family 39 member 12	ENSG00000148482	SLC39A12	chr10:17951839-18043292:+	Tbio	4.97619
salt inducible kinase 1	ENSG00000142178	SIK1	chr21:43414515-43427128:-	Tchem	59.272
ADAM metallopeptidase with thrombospondin type 1 motif 17	ENSG00000140470	ADAMTS17	chr15:99971589-100342005:-	Tbio	6.79444
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4	ENSG00000198886	MT-ND4	chrM:10760-12137:+	Tclin	272.861
PHD finger protein 2	ENSG00000197724	PHF2	chr9:93576407-93679587:+	Tbio	13.1936

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