PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| transient receptor potential cation channel subfamily C member 4 | ENSG00000133107 | TRPC4 | chr13:37636636-37870425:- | Tbio | 125.892 |
| chymotrypsin C | ENSG00000162438 | CTRC | chr1:15438439-15449242:+ | Tchem | 90.6028 |
| molybdenum cofactor synthesis 3 | ENSG00000124217 | MOCS3 | chr20:50958826-50963931:+ | Tbio | 9.94524 |
| guanosine monophosphate reductase | ENSG00000137198 | GMPR | chr6:16238580-16295549:+ | Tbio | 17.9357 |
| SCY1 like pseudokinase 3 | ENSG00000000457 | SCYL3 | chr1:169849631-169894267:- | Tdark | 3.14286 |
| aarF domain containing kinase 1 | ENSG00000063761 | ADCK1 | chr14:77800083-77935012:+ | Tdark | 0 |
| cartilage associated protein | ENSG00000170275 | CRTAP | chr3:33113979-33147773:+ | Tbio | 63.6857 |
| hormonally up-regulated Neu-associated kinase | ENSG00000142149 | HUNK | chr21:31873315-32044633:+ | Tchem | 14.7833 |
| fetuin B | ENSG00000090512 | FETUB | chr3:186635969-186653141:+ | Tbio | 9.92175 |
| cerebellin 4 precursor | ENSG00000054803 | CBLN4 | chr20:55997440-56005472:- | Tdark | 3.21212 |
| endo-beta-N-acetylglucosaminidase | ENSG00000167280 | ENGASE | chr17:79074939-79088599:+ | Tchem | 30.95 |
| alpha-2-macroglobulin like 1 | ENSG00000166535 | A2ML1 | chr12:8822472-8887001:+ | Tbio | 9.46428 |
| G protein-coupled receptor class C group 6 member A | ENSG00000173612 | GPRC6A | chr6:116792085-116829037:- | Tbio | 29.835 |
| hydroxycarboxylic acid receptor 3 | ENSG00000255398 | HCAR3 | chr12:122714756-122716892:- | Tbio | 72.2714 |
| NIM1 serine/threonine protein kinase | ENSG00000177453 | NIM1K | chr5:43192071-43280850:+ | Tbio | 5.83333 |
| methionyl aminopeptidase type 1D, mitochondrial | ENSG00000172878 | METAP1D | chr2:171999583-172082430:+ | Tbio | 4.53333 |
| cytochrome P450 family 2 subfamily A member 13 | ENSG00000197838 | CYP2A13 | chr19:41088472-41096195:+ | Tbio | 96.3935 |
| carbohydrate sulfotransferase 7 | ENSG00000147119 | CHST7 | chrX:46573784-46598408:+ | Tbio | 4.48978 |
| glutamate ionotropic receptor kainate type subunit 3 | ENSG00000163873 | GRIK3 | chr1:36795527-37034129:- | Tclin | 45.0166 |
| sodium voltage-gated channel beta subunit 1 | ENSG00000105711 | SCN1B | chr19:35030684-35040448:+ | Tbio | 62.5185 |
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