PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 38 member 4ENSG00000139209SLC38A4chr12:46764761-46832408:-Tbio23.2524
thioredoxin domain containing 16ENSG00000087301TXNDC16chr14:52430590-52552522:-Tdark4.53333
ATP/GTP binding protein like 2ENSG00000165923AGBL2chr11:47659591-47715389:-Tbio114.908
carboxypeptidase vitellogenic likeENSG00000106066CPVLchr7:28995231-29195451:-Tbio12.9088
solute carrier family 25 member 20ENSG00000178537SLC25A20chr3:48856931-48898993:-Tbio73.104
solute carrier family 25 member 33ENSG00000171612SLC25A33chr1:9539482-9585179:+Tbio12.065
killer cell lectin like receptor C1ENSG00000134545KLRC1chr12:10442264-10454685:-Tbio208.39
solute carrier family 30 member 9ENSG00000014824SLC30A9chr4:41990472-42090457:+Tbio5.97063
semenogelin 2ENSG00000124157SEMG2chr20:45221300-45224458:+Tbio51.9788
inhibitor of growth family member 5ENSG00000168395ING5chr2:241702035-241729478:+Tbio21.9747
inositol-trisphosphate 3-kinase CENSG00000086544ITPKCchr19:40717103-40740860:+Tbio32.0873
alanine--glyoxylate aminotransferase 2ENSG00000113492AGXT2chr5:34998101-35048135:-Tbio21.975
mitogen-activated protein kinase kinase kinase 10ENSG00000130758MAP3K10chr19:40191744-40215575:+Tchem30.5539
calpain 9ENSG00000135773CAPN9chr1:230747384-230802003:+Tbio9.61667
serine protease 50ENSG00000206549PRSS50chr3:46712116-46812574:-Tbio33.0873
leucine rich repeat containing 17ENSG00000128606LRRC17chr7:102912991-102944949:+Tdark3.46667
solute carrier family 35 member G2ENSG00000168917SLC35G2chr3:136818647-136855892:+Tdark1.2553
G protein-coupled receptor class C group 5 member DENSG00000111291GPRC5Dchr12:12940775-12952147:-Tdark8.03095
solute carrier family 25 member 39ENSG00000013306SLC25A39chr17:44319625-44324870:-Tbio2.64835
inositol polyphosphate-5-phosphatase KENSG00000132376INPP5Kchr17:1494571-1516888:-Tbio33.437

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