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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
mitochondrial carrier 2	ENSG00000109919	MTCH2	chr11:47617315-47642623:-	Tbio	17.017
signal peptide peptidase like 3	ENSG00000157837	SPPL3	chr12:120762510-120904371:-	Tbio	12.1107
arginine vasopressin	ENSG00000101200	AVP	chr20:3082556-3084724:-	Tbio	8222.01
cellular repressor of E1A stimulated genes 1	ENSG00000143162	CREG1	chr1:167529677-167553767:-	Tbio	41.3417
serine/threonine kinase 36	ENSG00000163482	STK36	chr2:218672026-218702716:+	Tbio	4.2447
solute carrier family 22 member 31	ENSG00000259803	SLC22A31	chr16:89195761-89201664:-	Tdark	0
aph-1 homolog B, gamma-secretase subunit	ENSG00000138613	APH1B	chr15:63276018-63309126:+	Tbio	10.3099
Fc receptor like 6	ENSG00000181036	FCRL6	chr1:159800511-159816251:+	Tdark	20.9274
solute carrier family 6 member 16	ENSG00000063127	SLC6A16	chr19:49289638-49325225:-	Tdark	2.30952
hydroxysteroid 17-beta dehydrogenase 14	ENSG00000087076	HSD17B14	chr19:48813017-48836678:-	Tchem	4.75
solute carrier family 12 member 4	ENSG00000124067	SLC12A4	chr16:67943474-67969601:-	Tbio	33.4123
NIMA related kinase 3	ENSG00000136098	NEK3	chr13:52132639-52159861:-	Tbio	9.90153
G protein-coupled receptor 27	ENSG00000170837	GPR27	chr3:71754050-71756496:+	Tdark	2.55675
carbohydrate sulfotransferase 8	ENSG00000124302	CHST8	chr19:33621955-33773509:+	Tbio	17.0179
lymphocyte antigen 86	ENSG00000112799	LY86	chr6:6588108-6654983:+	Tbio	8.10838
collagen type XXIII alpha 1 chain	ENSG00000050767	COL23A1	chr5:178237618-178590555:-	Tbio	5.05714
EMI domain containing 1	ENSG00000186998	EMID1	chr22:29205851-29259597:+	Tdark	0.111111
cysteine rich with EGF like domains 2	ENSG00000184164	CRELD2	chr22:49918167-49927540:+	Tbio	5.3754
endothelial cell adhesion molecule	ENSG00000149564	ESAM	chr11:124752583-124762290:-	Tbio	29.0673
taste 2 receptor member 5	ENSG00000127366	TAS2R5	chr7:141790217-141791367:+	Tbio	4.6

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