PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
twisted gastrulation BMP signaling modulator 1ENSG00000128791TWSG1chr18:9334767-9402420:+Tbio68.8952
unc-51 like kinase 3ENSG00000140474ULK3chr15:74836116-74843346:-Tchem7.28434
spexin hormoneENSG00000134548SPXchr12:21526307-21537377:+Tbio27.0667
solute carrier family 45 member 4ENSG00000022567SLC45A4chr8:141207166-141308305:-Tdark0
neudesin neurotrophic factorENSG00000117691NENFchr1:212432887-212446379:+Tbio6.84444
solute carrier family 22 member 16ENSG00000004809SLC22A16chr6:110424687-110476641:-Tbio21.5472
solute carrier family 27 member 4ENSG00000167114SLC27A4chr9:128340646-128361470:+Tchem34.2322
solute carrier family 24 member 5ENSG00000188467SLC24A5chr15:48120972-48142672:+Tbio32.9742
HHIP like 1ENSG00000182218HHIPL1chr14:99645110-99680569:+Tdark0.330357
serine/threonine kinase 32BENSG00000152953STK32Bchr4:5051442-5500998:+Tchem1.74762
FKBP prolyl isomerase 1CENSG00000198225FKBP1Cchr6:63211446-63213024:+0
solute carrier family 25 member 45ENSG00000162241SLC25A45chr11:65375192-65383701:-Tdark0.881685
guanylate cyclase 1 soluble subunit alpha 1ENSG00000164116GUCY1A3chr4:155666711-155732349:+Tclin12.2838
secretagogin, EF-hand calcium binding proteinENSG00000079689SCGNchr6:25652201-25701783:+Tbio17.3002
mitogen-activated protein kinase kinase kinase kinase 3ENSG00000011566MAP4K3chr2:39249266-39437312:-Tchem16.9111
dehydrogenase/reductase 12ENSG00000102796DHRS12chr13:51767993-51804157:-Tdark0
serine/threonine kinase 35ENSG00000125834STK35chr20:2101611-2177038:+Tchem6.58333
peptidoglycan recognition protein 2ENSG00000161031PGLYRP2chr19:15468645-15498956:-Tbio14.869
meteorin, glial cell differentiation regulatorENSG00000103260METRNchr16:715115-719655:+Tbio2.88889
reticulon 4 receptor like 1ENSG00000185924RTN4RL1chr17:1934677-2025345:-Tbio6.10397

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