PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| SUMO specific peptidase 7 | ENSG00000138468 | SENP7 | chr3:101324205-101513241:- | Tbio | 5.37738 |
| mannosidase beta | ENSG00000109323 | MANBA | chr4:102631488-102760994:- | Tchem | 57.2595 |
| dystroglycan 1 | ENSG00000173402 | DAG1 | chr3:49468703-49535618:+ | Tbio | 86.9356 |
| solute carrier family 52 member 1 | ENSG00000132517 | SLC52A1 | chr17:5032600-5052009:- | Tbio | 13.6667 |
| CD164 molecule like 2 | ENSG00000174950 | CD164L2 | chr1:27379176-27383380:- | Tdark | 1 |
| protein kinase N3 | ENSG00000160447 | PKN3 | chr9:128702523-128720918:+ | Tbio | 9.99841 |
| receptor activity modifying protein 2 | ENSG00000131477 | RAMP2 | chr17:42758447-42763041:+ | Tclin | 45.9909 |
| solute carrier family 39 member 5 | ENSG00000139540 | SLC39A5 | chr12:56230049-56237846:+ | Tbio | 6.15833 |
| solute carrier family 16 member 13 | ENSG00000174327 | SLC16A13 | chr17:7036075-7040121:+ | Tdark | 2.83333 |
| valyl-tRNA synthetase 2, mitochondrial | ENSG00000137411 | VARS2 | chr6:30908242-30926459:+ | Tbio | 10.609 |
| solute carrier family 25 member 22 | ENSG00000177542 | SLC25A22 | chr11:790475-798333:- | Tbio | 32.9929 |
| kelch like family member 12 | ENSG00000117153 | KLHL12 | chr1:202891100-202928636:- | Tbio | 7.74166 |
| succinate receptor 1 | ENSG00000198829 | SUCNR1 | chr3:151873643-151884619:+ | Tbio | 18.7893 |
| TAO kinase 1 | ENSG00000160551 | TAOK1 | chr17:29390464-29551904:+ | Tchem | 19.6607 |
| carbohydrate sulfotransferase 10 | ENSG00000115526 | CHST10 | chr2:100391860-100417656:- | Tbio | 11.3247 |
| TAO kinase 2 | ENSG00000149930 | TAOK2 | chr16:29973641-29992261:+ | Tchem | 146.263 |
| adhesion G protein-coupled receptor G3 | ENSG00000182885 | ADGRG3 | chr16:57668187-57689378:+ | Tbio | 3.09075 |
| phospholipase A2 group XV | ENSG00000103066 | PLA2G15 | chr16:68245304-68261062:+ | Tbio | 15.4621 |
| peptidase D | ENSG00000124299 | PEPD | chr19:33386950-33521794:- | Tchem | 444.579 |
| solute carrier family 2 member 13 | ENSG00000151229 | SLC2A13 | chr12:39755021-40106089:- | Tbio | 5.92063 |
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