PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
peptidylprolyl isomerase CENSG00000168938PPICchr5:123023250-123036741:-Tbio14.8179
pappalysin 2ENSG00000116183PAPPA2chr1:176463171-176845605:+Tbio26.9726
MSL complex subunit 3ENSG00000005302MSL3chrX:11758159-11775753:+Tbio6.65952
immunoglobulin superfamily member 8ENSG00000162729IGSF8chr1:160091340-160098943:-Tbio23.9429
lysophosphatidic acid receptor 6ENSG00000139679LPAR6chr13:48389567-48444704:-Tchem51.9786
phospholipase A2 group XIIBENSG00000138308PLA2G12Bchr10:72935170-72954778:-Tdark1.99567
ATP binding cassette subfamily D member 3ENSG00000117528ABCD3chr1:94418455-94518666:+Tbio60.4224
acrosin binding proteinENSG00000111644ACRBPchr12:6638075-6647460:-Tbio19.6179
recombination activating 2ENSG00000175097RAG2chr11:36575574-36598279:-Tbio312.383
NAD(P) dependent steroid dehydrogenase-likeENSG00000147383NSDHLchrX:152830967-152869729:+Tbio39.0929
C-C motif chemokine receptor 3ENSG00000183625CCR3chr3:46163604-46266706:+Tchem340.466
ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)ENSG00000111339ART4chr12:14825569-14843495:-Tbio26.7459
N-acetylglucosamine-1-phosphate transferase subunit gammaENSG00000090581GNPTGchr16:1351923-1364113:+Tbio21.2333
G protein-coupled receptor 15ENSG00000154165GPR15chr3:98531899-98533150:+Tbio516.977
fibroblast growth factor receptor like 1ENSG00000127418FGFRL1chr4:1009936-1026897:+Tbio26.1398
solute carrier family 33 member 1ENSG00000169359SLC33A1chr3:155821024-155854429:-Tchem12.3408
calcium/calmodulin dependent protein kinase II deltaENSG00000145349CAMK2Dchr4:113451032-113761927:-Tchem21.9742
purinergic receptor P2X 4ENSG00000135124P2RX4chr12:121209857-121234106:+Tchem136.931
dipeptidyl peptidase 8ENSG00000074603DPP8chr15:65442463-65517704:-Tchem58.2238
serine/threonine kinase 32AENSG00000169302STK32Achr5:147234963-147387852:+Tchem0.133929

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