PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| butyrophilin subfamily 2 member A2 | ENSG00000124508 | BTN2A2 | chr6:26383096-26394874:+ | Tdark | 10.5179 |
| interleukin 10 receptor subunit beta | ENSG00000243646 | IL10RB | chr21:33266358-33297234:+ | Tbio | 65.8924 |
| Wnt family member 1 | ENSG00000125084 | WNT1 | chr12:48978453-48981676:+ | Tbio | 347.697 |
| solute carrier family 38 member 2 | ENSG00000134294 | SLC38A2 | chr12:46358189-46372867:- | Tbio | 66.1615 |
| EGF like domain multiple 8 | ENSG00000241404 | EGFL8 | chr6:32164583-32168281:+ | Tdark | 9.12424 |
| CD302 molecule | ENSG00000241399 | CD302 | chr2:159768630-159798255:- | Tbio | 20.5125 |
| mitochondrially encoded ATP synthase membrane subunit 6 | ENSG00000198899 | MT-ATP6 | chrM:8527-9207:+ | Tbio | 292.723 |
| major intrinsic protein of lens fiber | ENSG00000135517 | MIP | chr12:56449502-56469166:- | Tbio | 237.252 |
| solute carrier family 25 member 44 | ENSG00000160785 | SLC25A44 | chr1:156193932-156212796:+ | Tdark | 0.315019 |
| nuclear receptor binding protein 2 | ENSG00000185189 | NRBP2 | chr8:143833594-143840974:- | Tdark | 0.924242 |
| solute carrier family 43 member 3 | ENSG00000134802 | SLC43A3 | chr11:57406954-57427580:- | Tdark | 3.75758 |
| gastrokine 1 | ENSG00000169605 | GKN1 | chr2:68974573-68980974:+ | Tbio | 41.131 |
| TGF-beta activated kinase 1 (MAP3K7) binding protein 3 | ENSG00000157625 | TAB3 | chrX:30827442-30975084:- | Tbio | 13.0763 |
| hephaestin | ENSG00000089472 | HEPH | chrX:66162549-66268867:+ | Tbio | 50.4762 |
| tryptase delta 1 | ENSG00000095917 | TPSD1 | chr16:1256059-1258998:+ | Tbio | 1.33333 |
| tryptase beta 2 | ENSG00000197253 | TPSB2 | chr16:1227272-1230184:- | 0 | |
| solute carrier family 29 member 3 | ENSG00000198246 | SLC29A3 | chr10:71319258-71363385:+ | Tbio | 70.2111 |
| glutathione S-transferase theta 2B | ENSG00000133433 | GSTT2B | chr22:23957414-23961186:- | Tbio | 5.90238 |
| fibroblast growth factor 23 | ENSG00000118972 | FGF23 | chr12:4368227-4379728:- | Tbio | 1313.79 |
| nuclear receptor coactivator 3 | ENSG00000124151 | NCOA3 | chr20:47501902-47656877:+ | Tbio | 296.594 |
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