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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
serpin family H member 1	ENSG00000149257	SERPINH1	chr11:75562056-75572783:+	Tbio	290.31
CD3d molecule	ENSG00000167286	CD3D	chr11:118338954-118342744:-	Tclin	98.9581
galectin 1	ENSG00000100097	LGALS1	chr22:37675608-37679806:+	Tchem	1537.16
REV3 like, DNA directed polymerase zeta catalytic subunit	ENSG00000009413	REV3L	chr6:111299028-111483715:-	Tbio	64.173
collagen type X alpha 1 chain	ENSG00000123500	COL10A1	chr6:116118923-116158747:-	Tbio	115.782
C-C motif chemokine ligand 19	ENSG00000172724	CCL19	chr9:34689567-34691277:-	Tbio	194.198
regulator of G protein signaling 4	ENSG00000117152	RGS4	chr1:163068775-163076802:+	Tchem	202.788
eukaryotic translation initiation factor 2 alpha kinase 4	ENSG00000128829	EIF2AK4	chr15:39934146-40035591:+	Tchem	86.8801
baculoviral IAP repeat containing 7	ENSG00000101197	BIRC7	chr20:63235883-63240507:+	Tbio	201.355
matrix metallopeptidase 12	ENSG00000262406	MMP12	chr11:102862736-102875034:-	Tchem	280.511
complement C6	ENSG00000039537	C6	chr5:41142234-41261438:-	Tbio	1125.86
TIMP metallopeptidase inhibitor 2	ENSG00000035862	TIMP2	chr17:78852977-78925387:-	Tbio	954.678
serpin family B member 5	ENSG00000206075	SERPINB5	chr18:63476761-63505085:+	Tbio	448.051
cytochrome P450 family 17 subfamily A member 1	ENSG00000148795	CYP17A1	chr10:102830531-102837533:-	Tclin	1117.97
growth hormone receptor	ENSG00000112964	GHR	chr5:42423777-42721878:+	Tclin	1302.54
programmed cell death 1 ligand 2	ENSG00000197646	PDCD1LG2	chr9:5510570-5571254:+	Tbio	123.393
protein tyrosine phosphatase receptor type C	ENSG00000081237	PTPRC	chr1:198638671-198757283:+	Tchem	2559.89
amphiregulin	ENSG00000109321	AREG	chr4:74445134-74455009:+	Tbio	302.481
NADPH oxidase 1	ENSG00000007952	NOX1	chrX:100843324-100874345:-	Tchem	204.963
cell division cycle 42	ENSG00000070831	CDC42	chr1:22052627-22092946:+	Tchem	1245.08

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