PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 5 member 12ENSG00000148942SLC5A12chr11:26667019-26723427:-Tdark2.81905
neurotensin receptor 2ENSG00000169006NTSR2chr2:11658178-11670164:-Tchem20.9179
ATPase H+ transporting V0 subunit e1ENSG00000113732ATP6V0E1chr5:172983757-173035445:+Tdark5.46667
bromodomain adjacent to zinc finger domain 2AENSG00000076108BAZ2Achr12:56595596-56636816:-Tchem26.6854
AP2 associated kinase 1ENSG00000115977AAK1chr2:69457997-69674349:-Tchem16.5429
ficolin 3ENSG00000142748FCN3chr1:27369112-27374824:-Tbio17.6667
follicle stimulating hormone receptorENSG00000170820FSHRchr2:48962157-49154537:-Tclin738.393
calpain 15ENSG00000103326CAPN15chr16:527717-554636:+Tbio6.2
ADAM metallopeptidase with thrombospondin type 1 motif 10ENSG00000142303ADAMTS10chr19:8580242-8610735:-Tbio23.2448
adhesion G protein-coupled receptor F1ENSG00000153292ADGRF1chr6:46997703-47042363:-Tbio5.28111
potassium voltage-gated channel subfamily H member 8ENSG00000183960KCNH8chr3:19148454-19535646:+Tclin1.67137
G protein-coupled receptor 84ENSG00000139572GPR84chr12:54362445-54364487:-Tchem9.20043
solute carrier family 35 member E1ENSG00000127526SLC35E1chr19:16549831-16572382:-Tdark0.333333
solute carrier family 10 member 6ENSG00000145283SLC10A6chr4:86823468-86849263:-Tdark6.27027
X-C motif chemokine ligand 2ENSG00000143185XCL2chr1:168540765-168543997:-Tbio7.51476
fukutin related proteinENSG00000181027FKRPchr19:46746046-46776988:+Tbio112.815
PHD finger protein 21AENSG00000135365PHF21Achr11:45929323-46121178:-Tbio3.52702
solute carrier family 30 member 2ENSG00000158014SLC30A2chr1:26037252-26046133:-Tbio25.6179
sodium voltage-gated channel beta subunit 2ENSG00000149575SCN2Bchr11:118161951-118176673:-Tbio10.7412
YME1 like 1 ATPaseENSG00000136758YME1L1chr10:27110112-27155266:-Tbio71.8885

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