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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
potassium voltage-gated channel subfamily H member 1	ENSG00000143473	KCNH1	chr1:210678315-211134115:-	Tclin	221.85
sialic acid binding Ig like lectin 12	ENSG00000254521	SIGLEC12	chr19:51491357-51501789:-	Tbio	2.16667
thioredoxin reductase 2	ENSG00000184470	TXNRD2	chr22:19875517-19941992:-	Tbio	84.3731
poly(ADP-ribose) polymerase family member 12	ENSG00000059378	PARP12	chr7:140023744-140063721:-	Tdark	2.17424
CD300c molecule	ENSG00000167850	CD300C	chr17:74541108-74546143:-	Tbio	57.052
short chain dehydrogenase/reductase family 42E, member 1	ENSG00000184860	SDR42E1	chr16:81988855-82011488:-	Tdark	0.333333
interferon lambda 3	ENSG00000197110	IFNL3	chr19:39243553-39245129:-	Tbio	1119.11
matrix metallopeptidase 26	ENSG00000167346	MMP26	chr11:4704927-4992429:+	Tchem	66.7188
luteinizing hormone/choriogonadotropin receptor	ENSG00000138039	LHCGR	chr2:48686775-48755730:-	Tclin	936.548
solute carrier family 25 member 30	ENSG00000174032	SLC25A30	chr13:45393316-45418455:-	Tdark	1
DnaJ heat shock protein family (Hsp40) member C10	ENSG00000077232	DNAJC10	chr2:182716041-182794464:+	Tbio	18.354
phosphatidylinositol glycan anchor biosynthesis class T	ENSG00000124155	PIGT	chr20:45416077-45426244:+	Tbio	10.8333
NAD(P)HX epimerase	ENSG00000163382	APOA1BP	chr1:156591762-156594299:+	Tbio	6.82619
CD163 molecule like 1	ENSG00000177675	CD163L1	chr12:7346685-7479897:-	Tbio	10.4131
neurexophilin 3	ENSG00000182575	NXPH3	chr17:49575858-49583827:+	Tdark	6.72619
phospholipase B domain containing 2	ENSG00000151176	PLBD2	chr12:113358566-113391625:+	Tbio	12.4143
solute carrier family 39 member 13	ENSG00000165915	SLC39A13	chr11:47407132-47416501:+	Tbio	8.35
gamma-glutamyltransferase 5	ENSG00000099998	GGT5	chr22:24219654-24245142:-	Tbio	12.6845
alpha-N-acetylgalactosaminidase	ENSG00000198951	NAGA	chr22:42058354-42070842:-	Tbio	123.567
MORC family CW-type zinc finger 3	ENSG00000159256	MORC3	chr21:36320189-36386148:+	Tbio	22.1278

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