PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
spindlin family member 3ENSG00000204271SPIN3chrX:56976370-56995537:-Tdark0
myosin IIIBENSG00000071909MYO3Bchr2:170178145-170655171:+Tbio3.93333
mucin 3A, cell surface associatedENSG00000169894MUC3Achr7:100949555-100968346:+Tdark11.454
solute carrier family 9 member B2ENSG00000164038SLC9B2chr4:103019868-103085829:-Tbio12.8429
C-type lectin domain containing 11AENSG00000105472CLEC11Achr19:50723329-50725718:+Tbio27.9117
slingshot protein phosphatase 3ENSG00000172830SSH3chr11:67303448-67312607:+Tdark1.44445
myotubularin related protein 6ENSG00000139505MTMR6chr13:25246201-25288009:-Tbio7.72692
melanocortin 4 receptorENSG00000166603MC4Rchr18:60371110-60372775:-Tchem744.088
CD5 molecule likeENSG00000073754CD5Lchr1:157830914-157898256:-Tbio22.1936
serine/threonine kinase 38ENSG00000112079STK38chr6:36493892-36547470:-Tbio90.7347
SET domain containing 5ENSG00000168137SETD5chr3:9397615-9479240:+Tbio6.1605
solute carrier family 17 member 2ENSG00000112337SLC17A2chr6:25912754-25930726:-Tbio2.46667
inositol polyphosphate-5-phosphatase EENSG00000148384INPP5Echr9:136428619-136439822:-Tbio24.9572
hyaluronan binding protein 4ENSG00000130956HABP4chr9:96450201-96491336:+Tbio10.75
solute carrier family 6 member 6ENSG00000131389SLC6A6chr3:14402576-14489349:+Tbio94.3738
cyclin dependent kinase 13ENSG00000065883CDK13chr7:39950037-40097134:+Tchem12.8566
solute carrier family 38 member 6ENSG00000139974SLC38A6chr14:60981114-61083733:+Tdark1.26667
dual specificity phosphatase 28ENSG00000188542DUSP28chr2:240560054-240564014:+Tbio3.75
solute carrier family 9 member A9ENSG00000181804SLC9A9chr3:143265222-143848531:-Tbio18.26
mitochondrially encoded cytochrome c oxidase IIENSG00000198712MT-CO2chrM:7586-8269:+Tchem7265.16

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