PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
N-acylethanolamine acid amidaseENSG00000138744NAAAchr4:75913657-75941051:-Tchem52.8127
M-phase phosphoprotein 8ENSG00000196199MPHOSPH8chr13:19633681-19673459:+Tbio12.2929
dual specificity phosphatase 14ENSG00000276023DUSP14chr17:37489831-37513501:+Tbio6.6042
testis specific serine kinase 4ENSG00000139908TSSK4chr14:24205697-24208362:+Tbio5.20833
chitobiaseENSG00000117151CTBSchr1:84549606-84574480:-Tbio67.1111
solute carrier family 46 member 2ENSG00000119457SLC46A2chr9:112878920-112890913:-Tdark7.5
EGF like domain multiple 6ENSG00000198759EGFL6chrX:13569605-13633575:+Tbio11.7044
extracellular matrix protein 2ENSG00000106823ECM2chr9:92493554-92536655:-Tdark3.60678
solute carrier family 20 member 2ENSG00000168575SLC20A2chr8:42416475-42541926:-Tbio98.7806
calpain 8ENSG00000203697CAPN8chr1:223538007-223665734:-Tbio13.3457
MT-RNR2 like 1ENSG00000256618MTRNR2L1chr17:22523111-22524663:+Tdark0
cytokine receptor like factor 2ENSG00000205755CRLF2chrX:1187549-1212750:-Tbio79.9595
testis specific serine kinase 3ENSG00000162526TSSK3chr1:32351521-32364312:+Tbio2.90278
zymogen granule protein 16ENSG00000174992ZG16chr16:29778240-29782973:+Tbio8.91111
solute carrier family 39 member 2ENSG00000165794SLC39A2chr14:20999255-21001871:+Tbio32.7675
potassium inwardly rectifying channel subfamily J member 13ENSG00000115474KCNJ13chr2:232766464-232776568:-Tbio33.3833
lemur tyrosine kinase 2ENSG00000164715LMTK2chr7:98106885-98209633:+Tbio26.932
exo/endonuclease GENSG00000157036EXOGchr3:38496127-38542161:+Tbio15.5429
nuclear receptor subfamily 2 group F member 6ENSG00000160113NR2F6chr19:17231883-17245940:-Tbio27.1079
transmembrane protein 123ENSG00000152558TMEM123chr11:102396332-102470384:-Tbio4.66667

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