PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ATP synthase F1 subunit betaENSG00000110955ATP5Bchr12:56638175-56646068:-Tbio34.04
potassium voltage-gated channel subfamily A member 4ENSG00000182255KCNA4chr11:30009741-30017023:-Tclin108.353
protein Z, vitamin K dependent plasma glycoproteinENSG00000126231PROZchr13:113158654-113172383:+Tbio5.94921
aldo-keto reductase family 7 member A3ENSG00000162482AKR7A3chr1:19282558-19289250:-Tbio6.25758
GDNF family receptor alpha 3ENSG00000146013GFRA3chr5:138252379-138274671:-Tbio20.3575
cytochrome P450 family 39 subfamily A member 1ENSG00000146233CYP39A1chr6:46549580-46652830:-Tbio5.81234
collagen type XXI alpha 1 chainENSG00000124749COL21A1chr6:56056590-56394094:-Tbio4.86806
solute carrier family 16 member 10ENSG00000112394SLC16A10chr6:111087503-111231194:+Tbio43.5135
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3ENSG00000243772KIR2DL3chr19:54724459-54767884:+Tbio171.3
complement C3a receptor 1ENSG00000171860C3AR1chr12:8058302-8066471:-Tchem67.8154
mannosidase alpha class 1B member 1ENSG00000177239MAN1B1chr9:137086927-137109187:+Tchem15.2338
microtubule associated monooxygenase, calponin and LIM domain containing 3ENSG00000243156MICAL3chr22:17787649-18024559:-Tbio2.24178
solute carrier family 39 member 11ENSG00000133195SLC39A11chr17:72645949-73092712:-Tbio2.9
serine/threonine kinase 24ENSG00000102572STK24chr13:98445185-98577940:-Tchem68.0663
thioredoxin domain containing 11ENSG00000153066TXNDC11chr16:11679080-11742878:-Tbio6.08333
gonadotropin releasing hormone receptorENSG00000109163GNRHRchr4:67739328-67754360:-Tclin603.81
calpain small subunit 1ENSG00000126247CAPNS1chr19:36139575-36150353:+Tbio39.2519
interferon alpha 2ENSG00000188379IFNA2chr9:21384254-21385388:-Tbio2763.52
G protein-coupled receptor 61ENSG00000156097GPR61chr1:109539872-109548406:+Tbio8.39107
signal regulatory protein beta 1ENSG00000101307SIRPB1chr20:1563521-1620061:-Tbio9.88926

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