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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
interleukin 34	ENSG00000157368	IL34	chr16:70579895-70660682:+	Tbio	39.3251
signal sequence receptor subunit 1	ENSG00000124783	SSR1	chr6:7268306-7347446:-	Tbio	45.6417
fibroblast growth factor binding protein 2	ENSG00000137441	FGFBP2	chr4:15960243-15969309:-	Tbio	7.98535
calcium/calmodulin dependent protein kinase I	ENSG00000134072	CAMK1	chr3:9757342-9769992:-	Tchem	56.2899
aquaporin 6	ENSG00000086159	AQP6	chr12:49967194-49977139:+	Tbio	19.0301
nucleobindin 1	ENSG00000104805	NUCB1	chr19:48900050-48923372:+	Tbio	129.51
prenylcysteine oxidase 1 like	ENSG00000145882	PCYOX1L	chr5:149358007-149369653:+	Tdark	0.571429
misshapen like kinase 1	ENSG00000141503	MINK1	chr17:4833388-4898061:+	Tchem	158.472
sclerostin	ENSG00000167941	SOST	chr17:43753731-43758788:-	Tbio	369.629
interleukin 1 receptor like 2	ENSG00000115598	IL1RL2	chr2:102186973-102240002:+	Tbio	11.0823
mannosidase alpha class 2A member 1	ENSG00000112893	MAN2A1	chr5:109689366-109869625:+	Tbio	301.927
interleukin 9 receptor	ENSG00000124334	IL9R	chrX:155997581-156010817:+	Tbio	45.4542
aminopeptidase O (putative)	ENSG00000148120	C9orf3	chr9:94726701-95087218:+	Tbio	85.1468
erythrocyte membrane protein band 4.2	ENSG00000166947	EPB42	chr15:43106225-43221283:-	Tbio	124.591
lymphocyte antigen 75	ENSG00000054219	LY75	chr2:159803355-159904749:-	Tbio	81.4306
collagen type XV alpha 1 chain	ENSG00000204291	COL15A1	chr9:98943179-99070792:+	Tbio	24.8494
gamma-aminobutyric acid type A receptor subunit epsilon	ENSG00000102287	GABRE	chrX:151953124-151974680:-	Tclin	14.2682
microtubule affinity regulating kinase 4	ENSG00000007047	MARK4	chr19:45079288-45305283:+	Tchem	28.6342
mucosal vascular addressin cell adhesion molecule 1	ENSG00000099866	MADCAM1	chr19:489176-505342:+	Tbio	92.9617
MOS proto-oncogene, serine/threonine kinase	ENSG00000172680	MOS	chr8:56112942-56113982:-	Tbio	517.273

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