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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
glutathione S-transferase alpha 3	ENSG00000174156	GSTA3	chr6:52847910-52909685:-	Tbio	41.7891
short chain dehydrogenase/reductase family 16C member 5	ENSG00000170786	SDR16C5	chr8:56300010-56320776:-	Tbio	4.05952
glycoprotein V platelet	ENSG00000178732	GP5	chr3:194394821-194398354:-	Tbio	249.179
chromodomain helicase DNA binding protein 2	ENSG00000173575	CHD2	chr15:92900189-93028005:+	Tbio	53.1819
selectin P ligand	ENSG00000110876	SELPLG	chr12:108622277-108633959:-	Tbio	649.999
protein kinase N1	ENSG00000123143	PKN1	chr19:14433053-14471867:+	Tchem	70.5225
solute carrier family 4 member 7	ENSG00000033867	SLC4A7	chr3:27372721-27484420:-	Tbio	50.3192
acid sensing ion channel subunit family member 4	ENSG00000072182	ASIC4	chr2:219514170-219538772:+	Tbio	6.42778
phosphoribosyl pyrophosphate synthetase 2	ENSG00000101911	PRPS2	chrX:12791355-12824222:+	Tbio	16.4365
mitogen-activated protein kinase kinase kinase 21	ENSG00000143674	MLK4	chr1:233327768-233385148:+	Tdark	4.09024
TATA-box binding protein associated factor 15	ENSG00000270647	TAF15	chr17:35713791-35864615:+	Tbio	48.2305
protein arginine methyltransferase 9	ENSG00000164169	PRMT9	chr4:147637785-147684230:-	Tbio	2.33333
fibulin 7	ENSG00000144152	FBLN7	chr2:112138385-112188216:+	Tbio	7.36667
gamma-aminobutyric acid type A receptor subunit theta	ENSG00000268089	GABRQ	chrX:152638183-152657534:+	Tclin	7.15758
endonuclease G	ENSG00000167136	ENDOG	chr9:128818474-128822677:+	Tbio	109.026
neurexin 3	ENSG00000021645	NRXN3	chr14:78242391-79868290:+	Tbio	15.0833
adhesion G protein-coupled receptor G5	ENSG00000159618	ADGRG5	chr16:57542421-57591681:+	Tdark	1.92317
EPH receptor A10	ENSG00000183317	EPHA10	chr1:37713880-37765133:-	Tbio	9.69454
protocadherin related 15	ENSG00000150275	PCDH15	chr10:53802771-55627942:-	Tbio	51.7674
plexin C1	ENSG00000136040	PLXNC1	chr12:94148723-94307675:+	Tbio	15.9689

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