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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
secretoglobin family 1D member 2	ENSG00000124935	SCGB1D2	chr11:62242210-62244808:+	Tbio	19.3878
FAM20A golgi associated secretory pathway pseudokinase	ENSG00000108950	FAM20A	chr17:68535113-68601389:-	Tbio	15.7
euchromatic histone lysine methyltransferase 1	ENSG00000181090	EHMT1	chr9:137618963-137870016:+	Tchem	64.4417
leucine rich repeat transmembrane neuronal 3	ENSG00000198739	LRRTM3	chr10:66926006-67099830:+	Tbio	6.83712
leucine rich repeats and immunoglobulin like domains 3	ENSG00000139263	LRIG3	chr12:58872149-58920522:-	Tbio	20.6623
follicular dendritic cell secreted protein	ENSG00000181617	FDCSP	chr4:70226071-70235252:+	Tbio	9.58452
mitogen-activated protein kinase 9	ENSG00000050748	MAPK9	chr5:180233143-180292099:-	Tchem	269.424
CaM kinase like vesicle associated	ENSG00000164076	CAMKV	chr3:49857988-49870222:-	Tbio	2.04545
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	ENSG00000167633	KIR3DL1	chr19:54724497-54867215:+	Tbio	216.273
solute carrier family 25 member 24	ENSG00000085491	SLC25A24	chr1:108134036-108200849:-	Tbio	13.9227
lanosterol synthase	ENSG00000160285	LSS	chr21:46188141-46228824:-	Tchem	27.2
NDUFA4 mitochondrial complex associated	ENSG00000189043	NDUFA4	chr7:10931951-10940256:-	Tclin	10.8964
tripeptidyl peptidase 2	ENSG00000134900	TPP2	chr13:102597003-102679958:+	Tbio	93.5429
BPI fold containing family B member 2	ENSG00000078898	BPIFB2	chr20:33007600-33023709:+	Tdark	2.68333
solute carrier family 4 member 10	ENSG00000144290	SLC4A10	chr2:161424332-161985282:+	Tbio	12.8274
methyltransferase like 21A	ENSG00000144401	METTL21A	chr2:207580631-207625928:-	Tbio	1.75
sphingomyelin phosphodiesterase acid like 3A	ENSG00000172594	SMPDL3A	chr6:122789049-122809720:+	Tbio	4.16667
cathepsin H	ENSG00000103811	CTSH	chr15:78921058-78949574:-	Tchem	101.005
collagen type XXVII alpha 1 chain	ENSG00000196739	COL27A1	chr9:114155560-114312511:+	Tbio	7.66667
cytochrome b5 reductase 2	ENSG00000166394	CYB5R2	chr11:7665100-7677222:-	Tbio	1.875

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