PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
bromo adjacent homology domain containing 1ENSG00000140320BAHD1chr15:40439721-40468242:+Tbio2.03333
mitogen-activated protein kinase kinase kinase 12ENSG00000139625MAP3K12chr12:53479669-53500063:-Tchem77.0589
carbonyl reductase 4ENSG00000145439CBR4chr4:168863770-169010275:-Tbio49.8762
histone deacetylase 5ENSG00000108840HDAC5chr17:44076746-44123702:-Tclin107.003
cytochrome P450 family 20 subfamily A member 1ENSG00000119004CYP20A1chr2:203238449-203305840:+Tdark169.516
kelch repeat and BTB domain containing 7ENSG00000120696KBTBD7chr13:41189833-41194566:-Tdark1.64286
adhesion G protein-coupled receptor F4ENSG00000153294ADGRF4chr6:47685864-47722021:+Tdark0.558882
solute carrier family 6 member 8ENSG00000130821SLC6A8chrX:153688099-153696593:+Tbio116.014
chloride voltage-gated channel KaENSG00000186510CLCNKAchr1:16018875-16034050:+Tchem23.7869
potassium two pore domain channel subfamily K member 10ENSG00000100433KCNK10chr14:88180103-88326907:-Tclin28.9198
G protein-coupled receptor 85ENSG00000164604GPR85chr7:113078331-113087778:-Tbio9.02571
presenilin associated rhomboid likeENSG00000175193PARLchr3:183829385-183884933:-Tbio46.6163
solute carrier family 41 member 1ENSG00000133065SLC41A1chr1:205789093-205813748:-Tbio35.3875
kelch like family member 26ENSG00000167487KLHL26chr19:18636965-18671714:+Tdark0
glucosidase alpha, neutral CENSG00000214013GANCchr15:42273233-42356935:+Tchem7.16667
protein arginine methyltransferase 3ENSG00000185238PRMT3chr11:20387530-20509294:+Tchem27.944
ST3 beta-galactoside alpha-2,3-sialyltransferase 2ENSG00000157350ST3GAL2chr16:70375978-70439237:-Tbio7.60996
RING1 and YY1 binding proteinENSG00000163602RYBPchr3:72371825-72446918:-Tbio27.6603
leucine rich repeat kinase 1ENSG00000154237LRRK1chr15:100919215-101078254:+Tbio18.3167
neuregulin 4ENSG00000169752NRG4chr15:75935969-76059795:-Tbio15.0059

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