PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ribonuclease A family member 4ENSG00000258818RNASE4chr14:20684100-20701215:+Tbio15.6
olfactomedin like 2AENSG00000185585OLFML2Achr9:124777158-124814885:+Tdark0.533333
poly(ADP-ribose) polymerase family member 10ENSG00000178685PARP10chr8:143977153-144012772:-Tchem12.125
sodium channel epithelial 1 subunit deltaENSG00000162572SCNN1Dchr1:1280436-1292029:+Tbio19.7333
tousled like kinase 2ENSG00000146872TLK2chr17:62458658-62615481:+Tchem8.92802
alpha tubulin acetyltransferase 1ENSG00000137343ATAT1chr6:30626842-30646823:+Tbio17.7595
tumor protein p53 inducible protein 3ENSG00000115129TP53I3chr2:24077433-24085861:-Tbio32.3878
myotubularin related protein 7ENSG00000003987MTMR7chr8:17298030-17413528:-Tdark1.06944
kelch like family member 25ENSG00000183655KLHL25chr15:85759323-85795030:-Tdark0.4
MAPK interacting serine/threonine kinase 2ENSG00000099875MKNK2chr19:2037465-2051244:-Tchem19.521
STAM binding proteinENSG00000124356STAMBPchr2:73828916-73873659:+Tbio34.3036
growth differentiation factor 11ENSG00000135414GDF11chr12:55743280-55757278:+Tbio38.4121
phospholipase A2 activating proteinENSG00000137055PLAAchr9:26904083-26947463:-Tchem91.4457
carboxylesterase 4AENSG00000172824CES4Achr16:66988589-67009758:+Tbio4.22778
inositol polyphosphate-5-phosphatase BENSG00000204084INPP5Bchr1:37860697-37947057:-Tbio18.9667
autoimmune regulatorENSG00000160224AIREchr21:44285838-44298648:+Tbio699.569
regulator of G protein signaling 12ENSG00000159788RGS12chr4:3293028-3439913:+Tbio14.4429
inositol monophosphatase 1ENSG00000133731IMPA1chr8:81657961-81686693:-Tclin159.907
glutamate ionotropic receptor kainate type subunit 5ENSG00000105737GRIK5chr19:41998321-42069498:-Tclin53.1818
phospholipid scramblase 1ENSG00000188313PLSCR1chr3:146515180-146544864:-Tbio75.965

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