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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
WAP four-disulfide core domain 2	ENSG00000101443	WFDC2	chr20:45469706-45481532:+	Tbio	296.253
fibroblast growth factor 2	ENSG00000138685	FGF2	chr4:122826708-122898236:+	Tchem	4323.26
C-X-C motif chemokine ligand 2	ENSG00000081041	CXCL2	chr4:74097035-74099293:-	Tbio	242.337
nucleophosmin 1	ENSG00000181163	NPM1	chr5:171387116-171411137:+	Tbio	988.345
cathepsin G	ENSG00000100448	CTSG	chr14:24573522-24576260:-	Tchem	655.63
chromogranin A	ENSG00000100604	CHGA	chr14:92923080-92935293:+	Tbio	2637.47
notch receptor 1	ENSG00000148400	NOTCH1	chr9:136494444-136545862:-	Tchem	1380.97
coagulation factor V	ENSG00000198734	F5	chr1:169514166-169586588:-	Tbio	3133.22
prolactin receptor	ENSG00000113494	PRLR	chr5:35048756-35230589:-	Tbio	452.905
BCL2 related protein A1	ENSG00000140379	BCL2A1	chr15:79960889-79971446:-	Tchem	786.279
ROS proto-oncogene 1, receptor tyrosine kinase	ENSG00000047936	ROS1	chr6:117288300-117425855:-	Tchem	175.659
periostin	ENSG00000133110	POSTN	chr13:37562583-37598844:-	Tbio	146.888
cytotoxic T-lymphocyte associated protein 4	ENSG00000163599	CTLA4	chr2:203867786-203873960:+	Tclin	2511.15
secretogranin II	ENSG00000171951	SCG2	chr2:223596940-223602503:-	Tbio	128.249
polypyrimidine tract binding protein 1	ENSG00000011304	PTBP1	chr19:797075-812327:+	Tbio	563.569
SET domain bifurcated histone lysine methyltransferase 2	ENSG00000136169	SETDB2	chr13:49444374-49495003:+	Tbio	5.34286
serine/threonine kinase 11	ENSG00000118046	STK11	chr19:1177558-1228435:+	Tchem	708.571
cyclin B2	ENSG00000157456	CCNB2	chr15:59105078-59125045:+	Tbio	41.4468
vimentin	ENSG00000026025	VIM	chr10:17228259-17237593:+	Tbio	6424.97
dihydropyrimidine dehydrogenase	ENSG00000188641	DPYD	chr1:97077743-97921049:-	Tclin	861.484

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