PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| aldo-keto reductase family 7 member A2 | ENSG00000053371 | AKR7A2 | chr1:19303965-19312146:- | Tbio | 125.198 |
| alkaline phosphatase, intestinal | ENSG00000163295 | ALPI | chr2:232456123-232460032:+ | Tbio | 550.526 |
| stromal interaction molecule 2 | ENSG00000109689 | STIM2 | chr4:26857678-27025381:+ | Tbio | 50.1325 |
| retinol dehydrogenase 11 | ENSG00000072042 | RDH11 | chr14:67676801-67695814:- | Tbio | 18.5461 |
| phosphoribosyl transferase domain containing 1 | ENSG00000099256 | PRTFDC1 | chr10:24848607-24952604:- | Tbio | 4.86667 |
| regenerating family member 1 beta | ENSG00000172023 | REG1B | chr2:79085030-79088019:- | Tbio | 31.0826 |
| PHD finger protein 21B | ENSG00000056487 | PHF21B | chr22:44881162-45009999:- | Tdark | 2.33333 |
| protein-L-isoaspartate (D-aspartate) O-methyltransferase | ENSG00000120265 | PCMT1 | chr6:149749443-149811420:+ | Tbio | 63.5211 |
| cyclin dependent kinase 19 | ENSG00000155111 | CDK19 | chr6:110609978-110815958:- | Tchem | 19.9779 |
| ribosomal protein S6 kinase C1 | ENSG00000136643 | RPS6KC1 | chr1:213051233-213274773:+ | Tdark | 4.19359 |
| odontogenic, ameloblast associated | ENSG00000109205 | ODAM | chr4:70196496-70204576:+ | Tbio | 34.4306 |
| phosphoinositide-3-kinase regulatory subunit 4 | ENSG00000196455 | PIK3R4 | chr3:130678935-130746829:- | Tbio | 10.3782 |
| atypical chemokine receptor 4 | ENSG00000129048 | ACKR4 | chr3:132597237-132618967:+ | Tbio | 20.942 |
| peptidylprolyl isomerase like 6 | ENSG00000185250 | PPIL6 | chr6:109390215-109441171:- | Tdark | 3.92619 |
| PHD finger protein 23 | ENSG00000040633 | PHF23 | chr17:7235028-7239722:- | Tbio | 3.06859 |
| poly(ADP-ribose) polymerase family member 9 | ENSG00000138496 | PARP9 | chr3:122527924-122564577:- | Tbio | 151.913 |
| tripartite motif containing 33 | ENSG00000197323 | TRIM33 | chr1:114392777-114511160:- | Tbio | 165.603 |
| sphingomyelin phosphodiesterase acid like 3B | ENSG00000130768 | SMPDL3B | chr1:27934993-27959157:+ | Tbio | 2.91667 |
| cytochrome c oxidase subunit 7B | ENSG00000131174 | COX7B | chrX:77899438-77907373:+ | Tbio | 3.18841 |
| multimerin 2 | ENSG00000173269 | MMRN2 | chr10:86935540-86969481:- | Tbio | 10.9373 |
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