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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
calmodulin-lysine N-methyltransferase	ENSG00000143919	CAMKMT	chr2:44361950-44772592:+	Tbio	9.16667
calpain 7	ENSG00000131375	CAPN7	chr3:15206152-15252918:+	Tbio	12.7833
transmembrane and coiled-coil domains 3	ENSG00000150403	TMCO3	chr13:113490995-113554590:+	Tdark	1.09091
podocan	ENSG00000174348	PODN	chr1:53062052-53085502:+	Tbio	11.15
5-phosphohydroxy-L-lysine phospho-lyase	ENSG00000175309	PHYKPL	chr5:178208497-178232791:-	Tdark	5.66667
solute carrier family 25 member 27	ENSG00000153291	SLC25A27	chr6:46652915-46678193:+	Tbio	32.2171
opsin 3	ENSG00000054277	OPN3	chr1:241590102-241677376:-	Tbio	13.8005
G protein-coupled receptor 65	ENSG00000140030	GPR65	chr14:88005124-88014811:+	Tbio	18.6837
osteomodulin	ENSG00000127083	OMD	chr9:92414245-92424461:-	Tbio	7.7
G protein-coupled receptor 75	ENSG00000119737	GPR75	chr2:53852913-53859989:-	Tdark	2.5119
FAM3 metabolism regulating signaling molecule C	ENSG00000196937	FAM3C	chr7:121348851-121396364:-	Tbio	13.2429
angiotensin II receptor type 2	ENSG00000180772	AGTR2	chrX:116170722-116174972:+	Tchem	841.526
solute carrier family 1 member 4	ENSG00000115902	SLC1A4	chr2:64988477-65023865:+	Tbio	41.2455
AT-rich interaction domain 4B	ENSG00000054267	ARID4B	chr1:235131634-235328219:-	Tbio	271.549
C-C motif chemokine ligand 13	ENSG00000181374	CCL13	chr17:34356452-34358610:+	Tbio	84.173
chitinase acidic	ENSG00000134216	CHIA	chr1:111290862-111320566:+	Tchem	197.455
leukocyte immunoglobulin like receptor A5	ENSG00000187116	LILRA5	chr19:54307070-54313139:-	Tbio	13.892
hydroxyacid oxidase 1	ENSG00000101323	HAO1	chr20:7882981-7940474:-	Tchem	788.417
methylcrotonoyl-CoA carboxylase 2	ENSG00000131844	MCCC2	chr5:71587288-71658704:+	Tbio	65.0595
transient receptor potential cation channel subfamily C member 5	ENSG00000072315	TRPC5	chrX:111774315-112082776:-	Tchem	114.071

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