PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
serine carboxypeptidase 1ENSG00000121064SCPEP1chr17:56978105-57006768:+Tbio174.428
sialic acid binding Ig like lectin 10ENSG00000142512SIGLEC10chr19:51410021-51417803:-Tbio12.8703
amylase alpha 2BENSG00000240038AMY2Bchr1:103553815-103579534:+Tbio26.4222
immunoglobulin superfamily member 11ENSG00000144847IGSF11chr3:118900557-119146068:-Tbio4.38395
CDC like kinase 4ENSG00000113240CLK4chr5:178602664-178630615:-Tchem7.23333
fatty acid amide hydrolase 2ENSG00000165591FAAH2chrX:57286706-57489196:+Tbio7.22946
serine peptidase inhibitor Kazal type 6ENSG00000178172SPINK6chr5:148202794-148215137:+Tbio32.3909
arylsulfatase GENSG00000141337ARSGchr17:68259182-68422731:+Tbio11.1667
ADAMTS like 3ENSG00000156218ADAMTSL3chr15:83654086-84039842:+Tbio7.20211
uncoupling protein 1ENSG00000109424UCP1chr4:140559434-140568805:-Tbio533.855
lysophosphatidylcholine acyltransferase 3ENSG00000111684LPCAT3chr12:6976186-7018510:-Tbio76.15
serpin family A member 7ENSG00000123561SERPINA7chrX:106032442-106038738:-Tbio946.048
interleukin 5ENSG00000113525IL5chr5:132541444-132556838:-Tclin2265.94
solute carrier family 16 member 8ENSG00000100156SLC16A8chr22:38078134-38084093:-Tbio14.4667
serine/threonine kinase 17bENSG00000081320STK17Bchr2:196133566-196176503:-Tchem15.454
insulin like 6ENSG00000120210INSL6chr9:5131979-5185668:-Tdark9.41978
Myb like, SWIRM and MPN domains 1ENSG00000162601MYSM1chr1:58654739-58700092:-Tbio7.2
cyclin T1ENSG00000129315CCNT1chr12:48688458-48716998:-Tchem193.476
PWWP domain containing 2BENSG00000171813PWWP2Bchr10:132397168-132417863:+Tdark0
serine/threonine kinase 39ENSG00000198648STK39chr2:167954020-168248141:-Tbio88.0336

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