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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
Kell metallo-endopeptidase (Kell blood group)	ENSG00000197993	KEL	chr7:142941114-142962681:-	Tbio	38.5429
Fc fragment of IgA and IgM receptor	ENSG00000162897	FCAMR	chr1:206957965-206970625:-	Tbio	12.0556
deoxyribonuclease 1 like 1	ENSG00000013563	DNASE1L1	chrX:154401238-154412112:-	Tbio	33.7095
granzyme H	ENSG00000100450	GZMH	chr14:24606480-24609699:-	Tbio	38.6385
serine/threonine kinase 10	ENSG00000072786	STK10	chr5:172042073-172188386:-	Tchem	84.9595
chitinase 3 like 2	ENSG00000064886	CHI3L2	chr1:111200771-111243440:+	Tbio	18.354
G protein-coupled receptor 83	ENSG00000123901	GPR83	chr11:94377311-94401419:-	Tbio	18.5952
VRK serine/threonine kinase 2	ENSG00000028116	VRK2	chr2:57907651-58159920:+	Tbio	23.5838
H3.3 histone B	ENSG00000132475	H3F3B	chr17:75776434-75785893:-	Tbio	12.5012
dehydrogenase/reductase 13	ENSG00000167536	DHRS13	chr17:28897781-28903071:-	Tdark	0
phosphatidylinositol 4-kinase beta	ENSG00000143393	PI4KB	chr1:151291797-151327715:-	Tchem	40.8458
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	ENSG00000183878	UTY	chrY:13248379-13480673:-	Tbio	15.1445
sodium voltage-gated channel alpha subunit 5	ENSG00000183873	SCN5A	chr3:38548057-38649673:-	Tclin	1244.8
retinoic acid early transcript 1G	ENSG00000203722	RAET1G	chr6:149916878-149923121:-	Tbio	6.56905
histone deacetylase 6	ENSG00000094631	HDAC6	chrX:48801377-48824982:+	Tclin	374.375
transmembrane serine protease 5	ENSG00000166682	TMPRSS5	chr11:113687550-113706373:-	Tdark	1.7
oxidative stress responsive kinase 1	ENSG00000172939	OXSR1	chr3:38165089-38255488:+	Tbio	7.35357
protein disulfide isomerase family A member 6	ENSG00000143870	PDIA6	chr2:10783391-10837977:-	Tbio	22.8873
ATPase phospholipid transporting 8A2	ENSG00000132932	ATP8A2	chr13:25372071-26025851:+	Tbio	119.935
ubiquitin specific peptidase 6	ENSG00000129204	USP6	chr17:5116438-5175034:+	Tbio	13.6667

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