PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
kirre like nephrin family adhesion molecule 2ENSG00000126259KIRREL2chr19:35855861-35867109:+Tbio14.7262
shisa family member 2ENSG00000180730SHISA2chr13:26044597-26051031:-Tdark1.75
nucleobindin 2ENSG00000070081NUCB2chr11:17208153-17349974:+Tbio171.854
dual specificity phosphatase 16ENSG00000111266DUSP16chr12:12474210-12562383:-Tbio18.6563
calcium/calmodulin dependent protein kinase IGENSG00000008118CAMK1Gchr1:209583717-209613938:+Tchem4.16026
guanylate cyclase 1 soluble subunit alpha 2ENSG00000152402GUCY1A2chr11:106674012-107018524:-Tclin0
calcium voltage-gated channel auxiliary subunit gamma 7ENSG00000105605CACNG7chr19:53909335-53943941:+Tdark3.38055
leukocyte immunoglobulin like receptor A2ENSG00000239998LILRA2chr19:54572920-54590287:+Tbio16.538
glucosylceramidase beta 2ENSG00000070610GBA2chr9:35736866-35749228:-Tchem22.5965
ATPase cation transporting 13A2ENSG00000159363ATP13A2chr1:16985958-17011928:-Tbio116.784
HDGF like 2ENSG00000167674HDGFRP2chr19:4472287-4502211:+Tbio104.533
lysine demethylase 6BENSG00000132510KDM6Bchr17:7839904-7854796:+Tchem68.0166
solute carrier family 6 member 15ENSG00000072041SLC6A15chr12:84859488-84913615:-Tbio16.785
protein tyrosine phosphatase non-receptor type 5ENSG00000110786PTPN5chr11:18727928-18792721:-Tchem20.569
1-acylglycerol-3-phosphate O-acyltransferase 2ENSG00000169692AGPAT2chr9:136673143-136687423:-Tchem67.1017
aldo-keto reductase family 1 member E2ENSG00000165568AKR1E2chr10:4786629-4848062:+Tbio25.6881
solute carrier family 30 member 1ENSG00000170385SLC30A1chr1:211571568-211578742:-Tbio63.8972
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaENSG00000170027YWHAGchr7:76326794-76359031:-Tbio39.364
lysine demethylase 5CENSG00000126012KDM5CchrX:53191321-53225422:-Tchem58.6624
dual specificity phosphatase 8ENSG00000184545DUSP8chr11:1554044-1571920:-Tbio16.2966

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