PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 24 member 1ENSG00000074621SLC24A1chr15:65611366-65660995:+Tbio36.4813
ubiquitin C-terminal hydrolase L3ENSG00000118939UCHL3chr13:75549480-75606020:+Tchem48.8123
FAM20C golgi associated secretory pathway kinaseENSG00000177706FAM20Cchr7:192969-260745:+Tbio40.6933
fibroblast growth factor 3ENSG00000186895FGF3chr11:69810224-69819024:-Tbio248.835
exostosin like glycosyltransferase 2ENSG00000162694EXTL2chr1:100872372-100895998:-Tbio10.2607
serine/threonine kinase 26ENSG00000134602STK26chrX:132023265-132075943:+Tchem19.6913
nuclear receptor binding SET domain protein 3ENSG00000147548WHSC1L1chr8:38269697-38382272:-Tbio16.3378
pregnancy up-regulated nonubiquitous CaM kinaseENSG00000130822PNCKchrX:153669730-153689010:-Tbio7.23333
solute carrier family 22 member 23ENSG00000137266SLC22A23chr6:3268962-3457022:-Tdark3.16667
SET domain containing 4ENSG00000185917SETD4chr21:36034541-36079389:-Tdark0.565909
presenilin enhancer, gamma-secretase subunitENSG00000205155PSENENchr19:35745114-35747519:+Tchem161.99
secretoglobin family 3A member 2ENSG00000164265SCGB3A2chr5:147870682-147882191:+Tbio24.2002
glutamate ionotropic receptor NMDA type subunit 2BENSG00000273079GRIN2Bchr12:13537337-13981957:-Tclin690.798
solute carrier family 30 member 7ENSG00000162695SLC30A7chr1:100896076-100981753:+Tbio5.25516
neurolysinENSG00000123213NLNchr5:65722196-65871725:+Tbio86.7778
G protein-coupled receptor 176ENSG00000166073GPR176chr15:39799023-39920892:-Tbio1.10714
vesicle amine transport 1ENSG00000108828VAT1chr17:43014605-43025123:-Tbio33.45
sialic acid binding Ig like lectin 6ENSG00000105492SIGLEC6chr19:51519525-51531856:-Tbio4.33333
solute carrier family 37 member 1ENSG00000160190SLC37A1chr21:42496008-42581440:+Tbio2.2
solute carrier family 25 member 34ENSG00000162461SLC25A34chr1:15736405-15741396:+Tdark0.398352

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