PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| mitogen-activated protein kinase kinase kinase 3 | ENSG00000198909 | MAP3K3 | chr17:63622415-63696303:+ | Tchem | 47.6722 |
| mitogen-activated protein kinase kinase 5 | ENSG00000137764 | MAP2K5 | chr15:67542709-67807123:+ | Tchem | 53.0625 |
| N-acetylated alpha-linked acidic dipeptidase like 1 | ENSG00000168060 | NAALADL1 | chr11:65044818-65058549:- | Tbio | 3.25 |
| G protein-coupled receptor 88 | ENSG00000181656 | GPR88 | chr1:100538137-100542018:+ | Tchem | 7.78571 |
| glutamine--fructose-6-phosphate transaminase 1 | ENSG00000198380 | GFPT1 | chr2:69319769-69387254:- | Tchem | 148.565 |
| solute carrier family 7 member 9 | ENSG00000021488 | SLC7A9 | chr19:32830509-32869766:- | Tbio | 110.662 |
| ubiquitin specific peptidase 1 | ENSG00000162607 | USP1 | chr1:62436297-62451804:+ | Tchem | 60.6087 |
| relaxin family peptide/INSL5 receptor 4 | ENSG00000173080 | RXFP4 | chr1:155941710-155942949:+ | Tbio | 13.0424 |
| ATPase phospholipid transporting 10B (putative) | ENSG00000118322 | ATP10B | chr5:160563120-160852214:- | Tdark | 0.572222 |
| WAP four-disulfide core domain 5 | ENSG00000175121 | WFDC5 | chr20:45109452-45115172:- | Tbio | 3.16944 |
| casein kinase 1 gamma 2 | ENSG00000133275 | CSNK1G2 | chr19:1941149-1981338:+ | Tchem | 8.00667 |
| carboxypeptidase A1 | ENSG00000091704 | CPA1 | chr7:130380339-130388114:+ | Tchem | 177.285 |
| angiopoietin like 7 | ENSG00000171819 | ANGPTL7 | chr1:11189341-11195981:+ | Tbio | 13.0243 |
| leukocyte immunoglobulin like receptor B5 | ENSG00000105609 | LILRB5 | chr19:54249431-54257301:- | Tbio | 2.18333 |
| myogenesis regulating glycosidase (putative) | ENSG00000164976 | KIAA1161 | chr9:34366670-34376853:- | Tbio | 0.5 |
| Pim-3 proto-oncogene, serine/threonine kinase | ENSG00000198355 | PIM3 | chr22:49960513-49964080:+ | Tchem | 54.0307 |
| interleukin 3 | ENSG00000164399 | IL3 | chr5:132060529-132063204:+ | Tbio | 1765.38 |
| phosphodiesterase 11A | ENSG00000128655 | PDE11A | chr2:177623252-178108339:- | Tchem | 49.5895 |
| phosphodiesterase 9A | ENSG00000160191 | PDE9A | chr21:42653636-42775509:+ | Tchem | 26.3972 |
| gamma-glutamyltransferase 6 | ENSG00000167741 | GGT6 | chr17:4556927-4560818:- | Tdark | 1.97619 |
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