PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
cytochrome b5 domain containing 2ENSG00000167740CYB5D2chr17:4143168-4187310:+Tdark3.16667
solute carrier family 13 member 1ENSG00000081800SLC13A1chr7:123113531-123199986:-Tbio18.5116
calpain 12ENSG00000182472CAPN12chr19:38730187-38769904:-Tdark0.266667
arylacetamide deacetylaseENSG00000114771AADACchr3:151814037-151828488:+Tbio90.4198
von Willebrand factor A domain containing 2ENSG00000165816VWA2chr10:114239330-114291513:+Tbio7.325
TAFA chemokine like family member 5ENSG00000219438FAM19A5chr22:48489460-48850912:+Tdark1.23333
sphingolipid transporter 2ENSG00000183018SPNS2chr17:4498838-4539035:+Tbio6.10119
CD300 molecule like family member fENSG00000186074CD300LFchr17:74694311-74712978:-Tbio19.1401
solute carrier family 31 member 2ENSG00000136867SLC31A2chr9:113150942-113164137:+Tbio25.3202
peroxisomal trans-2-enoyl-CoA reductaseENSG00000115425PECRchr2:215996329-216082955:-Tbio14.5
junction adhesion molecule likeENSG00000160593AMICA1chr11:118193740-118225094:-Tbio11.5611
aldehyde dehydrogenase 1 family member L2ENSG00000136010ALDH1L2chr12:105019784-105084577:-Tbio4.52571
scavenger receptor cysteine rich family member with 4 domainsENSG00000146700SSC4Dchr7:76389334-76409695:-Tdark1.56667
liver enriched antimicrobial peptide 2ENSG00000164406LEAP2chr5:132872322-132875046:+Tbio15.1103
tripartite motif containing 69ENSG00000185880TRIM69chr15:44728988-44767829:+Tbio4.68314
carbohydrate sulfotransferase 3ENSG00000122863CHST3chr10:71964365-72013564:+Tbio74.2711
chromosome 16 open reading frame 89ENSG00000153446C16orf89chr16:5044122-5066110:-Tbio0.533333
chloride channel accessory 1ENSG00000016490CLCA1chr1:86468368-86500289:+Tbio95.1393
aquaporin 8ENSG00000103375AQP8chr16:25215731-25228940:+Tbio72.0693
major facilitator superfamily domain containing 4BENSG00000173214KIAA1919chr6:111259348-111271167:+Tdark0.444444

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