PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
signal peptide, CUB domain and EGF like domain containing 3ENSG00000146197SCUBE3chr6:35214419-35253079:+Tbio9.68611
dual specificity phosphatase 7ENSG00000164086DUSP7chr3:52048919-52056550:-Tbio12.116
zinc finger RANBP2-type containing 1ENSG00000019995ZRANB1chr10:124942123-124988189:+Tbio4.08333
galanin receptor 1ENSG00000166573GALR1chr18:77250549-77277896:+Tchem62.794
platelet derived growth factor receptor likeENSG00000104213PDGFRLchr8:17576433-17644071:+Tbio14.3268
chorionic somatomammotropin hormone 2ENSG00000213218CSH2chr17:63872012-63881863:-Tbio1132.43
carboxypeptidase N subunit 2ENSG00000178772CPN2chr3:194339765-194351328:-Tdark14.4
aurora kinase A interacting protein 1ENSG00000175756AURKAIP1chr1:1373730-1375495:-Tchem2.53333
matrilin 2ENSG00000132561MATN2chr8:97868840-98036716:+Tbio17.9875
TUB like protein 3ENSG00000078246TULP3chr12:2877223-2941140:+Tbio5.43016
UDP glucuronosyltransferase family 1 member A4ENSG00000244474UGT1A4chr2:233718778-233773299:+Tbio160.955
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2ENSG00000203859HSD3B2chr1:119414931-119423035:+Tclin86.4372
phospholipase C like 2ENSG00000154822PLCL2chr3:16802651-17090594:+Tbio2.14359
Rh associated glycoproteinENSG00000112077RHAGchr6:49605158-49636839:-Tbio324.96
G protein-coupled receptor 162ENSG00000250510GPR162chr12:6821545-6829972:+Tbio29.6385
adenylate kinase 2ENSG00000004455AK2chr1:33007940-33080996:-Tbio52.249
ectodysplasin A receptorENSG00000135960EDARchr2:108894471-108989372:-Tbio101.409
serpin family B member 1ENSG00000021355SERPINB1chr6:2832332-2842006:-Tbio89.1522
coenzyme Q8AENSG00000163050ADCK3chr1:226897536-226987545:+Tbio17.9217
SNF related kinaseENSG00000163788SNRKchr3:43286512-43424764:+Tbio8.31667

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